黄芪甲苷对心脑血管疾病的现代药理作用研究进展  

Advances in Research on Pharmacological Effect of Astragaloside Ⅳ on Cardiovascular and Cerebrovascular Diseases

作　　者：孔祥琳 吕琴 李运伦[1] 阚东方[1] 裴可[1] 卜庆丰 张雅琪 武继彪[1] KONG Xiang-lin;LYU Qin;LI Yun-lun;KAN Dong-fang;PEI Ke;BU Qing-feng;ZHANG Ya-qi;WU Ji-biao(Shandong University of Traditional Chinese Medicine(TCM),Ji'nan 250355,China;Taian TCM Hospital,Taian 271000,China;Shandong College of TCM,Yantai 264010,China)

机构地区：[1]山东中医药大学,济南250355 [2]泰安市中医医院,泰安271000 [3]山东中医药高等专科学校,烟台264010

出　　处：《中国实验方剂学杂志》2021年第2期218-223,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：泰山学者建设工程项目(ts201712042)。

摘　　要：黄芪有补气固表、利尿托毒、排脓、敛疮生肌之效,不仅用于肺脾气虚、脾虚泄泻等证候,大剂量使用还可用于中风、胸痹等疾病,发挥补气活血功用。由于黄芪化学成分复杂,药理作用多样,其发挥补气活血的主要作用物质基础目前尚未明确。黄芪甲苷是其主要活性成分之一,近几年,国内外对黄芪甲苷的研究越来越多,报道显示,其具有增强机体免疫功能、强心降压、降低血糖、利尿、抗衰老和抗疲劳等药用价值,具有广泛的药理活性。其中,尤其对心脑血管疾病的作用日益受到人们重视。心脑血管疾病是由于血液黏稠、动脉粥样硬化、高血压、高脂血症等导致的心脏、大脑及全身组织发生的缺血性或出血性疾病,包括心血管和脑血管疾病。此类疾病严重威胁人类,是全球主要的病死原因。目前以西药治疗为主,不良反应多,远期效果预后不佳。中医认为气血失衡是该类疾病基本病机,气虚血瘀型较为常见,常采用益气活血之法,气血以流,经络所通。目前,黄芪甲苷在治疗心脑血管疾病方面已进行了多项研究,并取得了一定的成果,本文综述近年黄芪甲苷在治疗心脑血管疾病中发挥的药理活性,为探求黄芪甲苷是否是黄芪补气活血主要作用物质基础寻找理论依据,也为创新中医中药的药物研发奠定理论基础与实践指导。Astragalus membranaceus has the effect of tonifying Qi and solid surface,diuretic support poison,discharging pus and astringent sores to produce muscle. It is not only used for syndromes such as deficiency of lung and temper,deficiency of spleen and diarrhea,but also for stroke,chest obstruction and other diseases. Due to the complex chemical composition and diverse pharmacological effect of Astragalus membranaceus,and the main role in invigorating qi and activating blood circulation has not been clarified.Astragaloside Ⅳ is one of its main active ingredients. In recent years,more and more studies on Astragaloside Ⅳhave been conducted at home and abroad. It has been reported that it has the medicinal value of enhancing immune function,strengthening heart and lowerin blood glucose,diuresis,anti-aging and anti-fatigue,et al,and has extensive pharmacological activity. Among them,the role of cardiovascular and cerebrovascular diseases in particular has attracted increasing attention. Cardiovascular and cerebrovascular diseases are ischemic or hemorrhagic diseases occurring in the heart,brain and systemic tissues due to blood viscosity,atherosclerosis,hypertension,hyperlipidemia,etc.,including cardiovascular and cerebrovascular diseases. Such diseases are a serious threat to mankind and are the leading cause of death worldwide. At present,western medicine is the main treatment,with many adverse reactions and poor long-term prognosis. TCM believes that the imbalance of qi and blood is the basic pathogenesis of this kind of disease. Qi deficiency and blood stasis are more common. At present,Astragaloside Ⅳ in the treatment of cardiovascular and cerebrovascular diseases in a number of studies,and achieved some results,but this review in recent years,Astragaloside Ⅳ in the treatment of cardiovascular and cerebrovascular diseases play the pharmacological activity,in order to explore whether Astragaloside Ⅳ is the main role of astragalus qi to find a theoretical basis for material basis,but also for the innovation

关 键 词：黄芪甲苷 心血管 脑血管 补气活血 现代药理作用 研究进展 

分 类 号：R2-0[医药卫生—中医学] R289[医药卫生—方剂学]