腈类化合物的合成进展  

Progress in the Synthesis of Nitriles

作　　者：陈婷婷[1,2] 李珍名 辛宇 阮建成 陈新志[1,2] CHEN Ting-ting;LI Zhen-ming;XIN Yu;RUAN Jian-cheng;CHEN Xin-zhi(College of Chemical and Biological Engineering,Zhejiang University,Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology,Hangzhou,Zhejiang 310027,China;Institute of Zhejiang University-Quzhou,Quzhou,Zhejiang 324000,China;Sichuan Zhijiang High-tech Material Co.,Ltd.,Suining,Sichuan 629100,China)

机构地区：[1]浙江大学化学工程与生物工程学院,浙江省化工高效制造技术重点实验室,浙江杭州310027 [2]浙江大学衢州研究院,浙江衢州324000 [3]四川之江高新材料股份有限公司,四川遂宁629100

出　　处：《浙江化工》2021年第2期14-19,共6页Zhejiang Chemical Industry

基　　金：国家自然科学基金“连续化合成手性胺的催化剂及其催化机理研究”(21376213)。

摘　　要：腈类化合物是重要的精细化工原料和合成中间体,不仅可以水解制备酸、还原成胺,还能发生许多其他的反应,被广泛用于制备医药、涂料、香料、液晶材料和缓蚀剂等。制备腈类化合物的方法众多,本文从氨氧化法、卤代烃氰化法、重氮盐法、醛肟脱水法、酰胺脱水法概述腈类化合物的合成进展,并讨论了这些方法的优缺点。Nitriles are important fine chemical raw materials and synthetic intermediates.They can not only hydrolyze to produce acids and reduce to amines,but also produce many other reactions.They are widely used in the preparation of medicines,coatings,perfumes,liquid crystal materials and corrosion inhibitors.There are many methods for preparing nitriles.In this paper,the synthesis progress of nitriles from the ammoxidation method,halogenated hydrocarbon cyanidation method,diazonium salt method,aldoxime dehydration method,and amide dehydration method are summarized,and the advantages and disadvantages of these methods are discussed.

关 键 词：腈类化合物 制备 进展 工业化 

分 类 号：TQ226.61[化学工程—有机化工]