病毒感染性疾病与肠道微生物关系研究进展  

Gut microbiota in human virus infection

作　　者：曹德民 宋晓峰 朱宝利 Demin Cao;Xiaofeng Song;Baoli Zhu(Savaid Medical School,University of Chinese Academy of Sciences,Beijing 100049,China;CAS Key Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China;Chinese Center for Disease Control and Prevention(China CDC),Beijing 102206,China;Beijing Key Laboratory of Antimicrobial Resistance and Pathogen Genomics,Beijing 100101,China;Department of Pathogenic Biology,School of Basic Medical Sciences,Southwest Medical University,Luzhou 646000,Sichuan Province,China)

机构地区：[1]中国科学院大学存济医学院,北京100049 [2]中国科学院病原微生物与免疫学重点实验室,北京100101 [3]中国疾病预防控制中心传染病预防控制所,北京102206 [4]病原微生物耐药与耐药基因组学北京市重点实验室,北京100101 [5]西南医科大学基础医学院,四川泸州646000

出　　处：《微生物学报》2021年第1期13-24,共12页Acta Microbiologica Sinica

基　　金：中国科学院战略性光导科技专项(XDB29020203);国家科技重大专项(2018ZX10201-001)。

摘　　要：肠道微生物影响着人体的营养、代谢、免疫等多种生理活动,对人体健康有非常重要的影响。目前的研究表明,肠道微生物在病毒感染性疾病的感染及预后过程中发挥着重要的作用。本文分别总结了肠道病毒感染、非肠道病毒感染与肠道微生物的相互作用关系以及微生态调节干预病毒感染等内容,以期为相关研究的进一步深入和病毒感染性疾病的防治提供新思路。Gut microbiota affects human nutrition,metabolism,immune development and functionality,and other physiological activities.Recent findings have revealed the roles of gut microbiota in susceptibility and prognosis in virus infection diseases.Here,we summarize the relationship,interaction between gut microbiota and enteric virus infection diseases,as well as non-enteric virus infection diseases.In addition,the potential therapies for modulating microbiota to prevent or treat virus infection diseases are discussed.This review will provide new ideas for further related research on prevention and control of virus infection diseases.

关 键 词：肠道微生物 病毒感染性疾病 免疫系统 抗病毒 

分 类 号：R37[医药卫生—病原生物学]