CYP2C19基因与氯吡格雷关系研究的文献计量学及可视化分析  

Bibliometrics and visual analysis of the relationship between CYP2C19 gene polymorphisms and Clopidogrel

作　　者：孙雪[1] 格桑罗布[2] 张令军[2] 泽碧[1] 白玛央宗[1] 杜小莉[3] 赵彬[3] SUN Xue;GESANG-Luobu;ZHANG Ling-jun;ZE Bi;BAIMA-Yangzong;DU Xiao-li;ZHAO Bin(Department of Pharmacyy,People's Hospital of the Tibet Autonomous Region,Altitude Disease Research Institute,Lasa;Department of Vasculocardiology,People's Hospital of the Tibet Autonomous Region,Altitude Disease Research Institute,Lasa 850000,China;Department of Pharmacy,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Science,Beijing 100730,China)

机构地区：[1]西藏自治区人民医院药学部,拉萨850000 [2]西藏自治区人民医院心血管内科西藏高原医学研究所,拉萨850000 [3]中国医学科学院北京协和医学院北京协和医院药剂科,北京100730

出　　处：《临床药物治疗杂志》2021年第2期36-39,共4页Clinical Medication Journal

基　　金：西藏自然科学基金(XZ2017ZR-ZYZ26)。

摘　　要：目的通过文献计量学及可视化分析方法针对CYP2C19基因与氯吡格雷关系,研究其现状、热点及发展趋势。方法以Web of Science数据库为数据源,使用VOSviewer 1.6.13绘制网络图谱,分析CYP2C19基因与氯吡格雷的研究趋势。结果共检索出符合要求的文献202篇,发文量整体呈逐年上升趋势;研究方向集中在药理学、心血管系统学和血液学方面;发文量最多的杂志是Thrombosis Research;最多的作者是Hulot J S。结论氯吡格雷的基因多态性研究从早期药物代谢逐步发展到真实世界不良临床结局。目前研究热点为基于血小板功能和基因检测的精准治疗,从多基因位点、病理生理学、药物相互作用等多因素评价疗效差异。Objective To highlight the scientific progress,research status and development trend in CYP2C19 gene poly⁃morphisms and Clopidogrel by bibliometric analysis and visual analysis.Methods The published relevant literatures on CYP2C19 and Clopidogrel were retrieved from the Web of Science.Cooperation network maps were generated using VOSview⁃er 1.6.13 to analyze the research trend of CYP2C19 and Clopidogrel.Results A total of 202 literatures were retrieved,the number of published literatures showed an increasing trend year by year.Pharmacology,cardiovascular system cardiology,and hematology were the current research hotspots.The top journal with the most published articles was Thrombosis Re⁃search.The top author with the most published articles was Hulot J S.Conclusion The research of genetic polymorphism of Clopidogrel has evolved from early drug metabolism to real world clinical adverse outcomes.At present,the focus of research is precision therapy based on platelet function and gene testing,and the difference in efficacy can be evaluated from multiple factors such as gene polymorphism,pathophysiology and drug interactions.

关 键 词：氯吡格雷 文献计量学 可视化分析 热点研究 

分 类 号：R973.2[医药卫生—药品]