临床实验室应对突发公共卫生事件体系与能力建设专家共识  

Update on cellular senescence and age-related diseases

作　　者：中国研究型医院学会检验医学专业委员会 府伟灵 王传新 邓昆 张晓丽 Committee of Laboratory Medicine of the Chinese Research Hospital Association

机构地区：[1]不详 [2]陆军军医大学第一附属医院 [3]山东大学第二医院 [4]重庆医科大学附属第三医院 [5]重庆医科大学附属永川医院

出　　处：《中华检验医学杂志》2021年第1期12-24,共13页Chinese Journal of Laboratory Medicine

摘　　要：新型冠状病毒肺炎疫情全球暴发,临床实验室作为病原微生物检测第一线,其应对突发公共卫生事件的能力在疫情的发现和控制中发挥重要作用。中国研究型学会检验医学专业委员会围绕临床实验室应急能力与体系规范化建设的核心内容,参照国家法律法规、国家标准、行业标准、指南规范等相关文件,制定本共识。聚焦临床实验室应急管理的实际问题,对临床实验室应急队伍建设和管理、应急设施配置和管理、应急通讯和信息管理、应急生物安全管理、应急准备和响应机制相关要求进行阐述和介绍,旨在提升全国各级临床实验室的应急及处理突发事件的能力。Cells are the basic structural units of organs and tissues.Cell senescence is one of the main reasons and primary causes of geriatric diseases.The oxidative stress and the expression of age-related genes(such as p16INK4a)increase significantly in the ageing cells,which could promote Aβdeposition and tau assembling,the formation of atherosclerotic plaque.The accumulation of the advanced glycation end products(AGEs)in ageing cells could trigger and promote lens degeneration,as well as the metabolic decline of glucose.Meanwhile,cell senescence is responsible for the decrease of insulin synthesis and osteoblast.Moreover,several biomarkers of cellular senescence(such as AGEs,age-related genes,etc)are the potential useful biomarkers for the age-related diseases in the early warning,diagnosis and prediction of prognosis.

关 键 词：临床实验室 突发公共卫生事件 应急能力 应急管理体系 

分 类 号：R197.1[医药卫生—卫生事业管理]