野山参中1个新的聚炔类化合物  

A new polyacetylene from wild ginseng

作　　者：牛雪妮 罗文 吕重宁 路金才[1] NIU Xue-ni;LUO Wen;LYU Chong-ning;LU Jin-cai(School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China)

机构地区：[1]沈阳药科大学中药学院,辽宁沈阳110016

出　　处：《中草药》2021年第1期23-27,共5页Chinese Traditional and Herbal Drugs

基　　金：国家重点研发计划项目(2017YFC1702302)。

摘　　要：目的研究野山参Panax ginseng根与根茎的化学成分。方法利用HPD-400大孔吸附树脂和反相硅胶柱色谱以及半制备高效液相色谱等方法进行分离纯化,通过质谱、核磁共振波谱(^(1)H-和^(13)C-NMR以及HSQC、HMBC实验)等手段鉴定化合物结构。结果从野山参70%乙醇提取物经HPD-400大孔吸附树脂90%乙醇洗脱部位分离得到5个化合物,分别鉴定为8Z-癸烷-4,6-二炔-1-O-β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃葡萄糖苷(1)、三七皂苷Rt(2)、20(E)-人参皂苷F_(4)(3)、人参皂苷Rg_(6)(4)、20(E)-人参皂苷Rg_(9)(5)。结论化合物1为新的聚炔类化合物,命名为人参炔氧苷A;化合物2~5为首次从野山参中分离得到。Objective To study the chemical constituents from the root and rhizome of wild ginseng(Panax ginseng).Methods HPD-400 macroporous resin column chromatography,reversed phase silica gel column chromatography,semi-preparative HPLC methods were used for separation and purification,and mass spectrometry,nuclear magnetic resonance spectroscopy(^(1) H-NMR,^(13)C-NMR,HSQC and HMBC)were analyzed to identify compound structures.Results Five compounds were isolated from the 90%ethanol fraction of the 70%ethanol extract eluated by HPD-400 macroporous absorption resin from the root and rhizome of wild ginseng,and elucidated as 8 Z-decane-4,6-diyn-1-O-β-D-glucopyranosyl-(1-2)-β-D-glucopyranoside(1),notoginsenoside Rt(2),20(E)-ginsenoside F_(4)(3),ginsenoside Rg_(6)(4)and 20(E)-ginsenoside Rg_(9)(5).Conclusion Compound 1 is a new polyacetylene,named as panaxyneoside A.Compounds 2—5 are isolated from wild ginseng for the first time.

关 键 词：野山参 人参 人参炔氧苷A 聚炔类化合物 人参皂苷 三七皂苷Rt 20(E)-人参皂苷F_(4) 人参皂苷Rg_(6) 

分 类 号：R284.1[医药卫生—中药学]