甘草“调和诸药”生物药剂学机制的研究进展  

Research progress on biopharmaceutical mechanism of Glycyrrhiza uralensis“moderating property of herbs”

作　　者：罗子宸 张雯[1,2] 杨瑞 单进军 狄留庆[1,2] LUO Zi-chen;ZHANG Wen;YANG Rui;SHAN Jin-jun;DI Liu-qing(School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China;Jiangsu Engineering Research Center for Efficient Delivery System of TCM,Nanjing University of Chinese Medicine,Nanjing 210023,China;Jiangsu Key Laboratory of Pediatric Respiratory Disease(TCM),Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学药学院,江苏南京210023 [2]南京中医药大学江苏省中药高效给药系统工程技术研究中心,江苏南京210023 [3]南京中医药大学江苏省儿童呼吸疾病(中医药)重点实验室,江苏南京210023

出　　处：《中草药》2021年第1期267-277,共11页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81774156);国家自然科学基金资助项目(81273655);国家自然科学基金资助项目(81001499);江苏省“六大人才高峰”高层次人才选拔培养资助项目(YY-022);江苏省研究生科研与实践创新计划(SJKY19_1457)。

摘　　要：甘草在中药复方中应用广泛,能够解毒、调和诸药,被称为药中"国老"。甘草活性成分在现代临床中也可与各种化学药物或天然产物单体联合用药。甘草及其活性成分的配伍用药作用机制可能与其改变药物的溶解度或体内代谢过程等生物药剂学特性有关。综合国内外相关研究表明,甘草酸在甘草体外增溶方面起主要作用;药物跨膜转运能力的改变也多与甘草酸及其苷元甘草次酸有关;而甘草黄酮类成分则在影响药物的体内代谢方面发挥了重要作用。Glycyrrhiza uralensis,known as"Guo lao"in Chinese materia medica,is widely used in Chinese herbal compounds,which has the effect of reducing drug toxicity and improving drug efficacy.Active ingredients of G.uralensis are often used in combination with various chemical drugs or natural product phytochemicals in modern clinical practice.The mechanism of interactions between G.uralensis and other drugs may be related to the change of the biopharmaceutical process of drug,such as solubility and ADME.The results of various studies show that glycyrrhizic acid plays a major role in solubilizing drugs in vitro,while changes in the membrane transport capacity of drugs are mostly related to glycyrrhizic acid and glycyrrhetic acid.Moreover,flavonoids play major role in changing the liver metabolism of drugs.

关 键 词：甘草 甘草酸 甘草次酸 黄酮类成分 药物相互作用 增溶 跨膜转运 代谢 

分 类 号：R285.62[医药卫生—中药学]