补骨脂素药理作用及肝毒性机制的研究进展  

Research progress on mechanism of pharmacological effects and hepatotoxicity of psoralen

作　　者：杨阔 高茸 马亚中 申宝德 杭凌宇 袁海龙 YANG Kuo;GAO Rong;MA Ya-zhong;SHEN Bao-de;HANG Ling-yu;YUAN Hai-long(College of Pharmacy,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;Department of Pharmacy,Air Force Medical Center,PLA,Beijing 100142,China)

机构地区：[1]江西中医药大学药学院,江西南昌330004 [2]中国人民解放军空军特色医学中心药学部,北京100142

出　　处：《中草药》2021年第1期289-298,共10页Chinese Traditional and Herbal Drugs

基　　金：国家新药创制重大专项(2016ZX09101073);军队后勤重点项目(BKJ15J005)。

摘　　要：补骨脂素是源于补骨脂Psoralea corylifolia的香豆素成分,具有抗骨质疏松、神经保护、抗肿瘤、雌激素样、抗炎等多重药理作用,有着良好的临床应用潜力。随着对补骨脂用药安全问题的不断关注,近年来关于补骨脂素的肝脏毒性研究也逐渐增多。通过查阅近20年国内外相关文献,对补骨脂素的药理作用和肝毒性研究概况进行整理和总结,为补骨脂素的进一步研究和临床应用提供参考。Psoralen is a coumarin component derived from Psoralea corylifolia.It has multiple pharmacological effects,such as anti-osteoporosis,neuroprotective,anti-tumor,estrogen-like,and anti-inflammatory,which has a good application potential in clinic.With the increasing attention paid to the safety of psoralen,studies on liver toxicity caused by psoralen have been gradually increasing in recent years.The pharmacological effects and hepatotoxicity of psoralen in the past 20 years were reviewed in this paper,in order to provide reference for the further research and clinical application of psoralen.

关 键 词：补骨脂 补骨脂素 药理作用 肝毒性 作用机制 抗骨质疏松 神经保护 抗肿瘤 雌激素样 抗炎 

分 类 号：R282.71[医药卫生—中药学]