小儿肺炎支原体肺炎予阿奇霉素序贯治疗的效果及对血清CRP、G-CSF水平的影响分析  

Effect of azithromycin sequential therapy on Mycoplasma pneumoniae in children and its influence on serum CRP and G-CSF

作　　者：姜楠 JIANG Nan(Department of Pediatrics,Ans han Central Hospital,Anshan 114000,China)

机构地区：[1]鞍山市中心医院儿科,114000

出　　处：《中国实用医药》2021年第6期16-18,共3页China Practical Medicine

摘　　要：目的观察小儿肺炎支原体肺炎行阿奇霉素序贯治疗的疗效以及对血清C反应蛋白(CRP)、粒细胞集落刺激因子(G-CSF)水平的影响。方法96例肺炎支原体肺炎患儿,采用抽签法随机分为实验组与对照组,每组48例。对照组患儿接受常规治疗,实验组患儿接受阿奇霉素序贯治疗。比较两组患儿体征恢复正常时间、治疗效果、血清指标(CRP、G-CSF)水平、不良反应发生情况。结果实验组患儿的咳嗽恢复正常时间、啰音恢复正常时间和体温恢复正常时间均短于对照组,差异具有统计学意义(P<0.05)。实验组治疗总有效率95.83%(46/48)高于对照组的83.33%(40/48),差异具有统计学意义(χ^(2)=4.019,P=0.045<0.05)。治疗后,实验组CRP(48.61±6.56)mg/L、G-CSF(8.12±1.11)pg/ml均低于对照组的(90.31±12.23)mg/L、(13.43±2.66)pg/ml,差异具有统计学意义(P<0.05)。实验组患儿不良反应发生率12.50%(6/48)低于对照组的47.92%(23/48),差异具有统计学意义(χ^(2)=14.279,P=0.000<0.05)。结论小儿肺炎支原体肺炎患儿使用阿奇霉素序贯治疗,可以改善患儿血清CRP、G-CSF水平,提高治疗效果,缩短体征恢复时间,具有临床推广价值。Objective To observe the efficacy of azithromycin sequential therapy on Mycoplasma pneumoniae in children and its influence on serum C-reactive protein(CRP)and granulocyte colony stimulating factor(G-CSF).Methods A total of 96 children with Mycoplasma pneumoniae were divided into experimental group and control group according to lottery method,with 48 patients in each group.The control group received conventional therapy,and the experimental group received azithromycin sequential therapy.The recovery time of signs,therapeutic effect,the levels of serum indexes(CRP,G-CSF),and the occurrence of adverse reactions were compared between the two groups.Results The recovery time of cough,lung rales and body temperature of the experimental group were shorter than those of the control group,and the difference was statistically significant(P<0.05).The total effective rate of treatment 95.83%(46/48)of the experimental group was higher than 83.33%(40/48)of the control group,and the difference was statistically significant(χ^(2)=4.019,P=0.045<0.05).After treatment,the CRP(48.61±6.56)mg/L and G-CSF(8.12±1.11)pg/ml of the experimental group were lower than(90.31±12.23)mg/L and(13.43±2.66)pg/ml of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions 12.50%(6/48)of the experimental group was lower than 47.92%(23/48)of the control group,and the difference was statistically significant(χ^(2)=14.279,P=0.000<0.05).Conclusion Azithromycin sequential therapy can improve the serum CRP and G-CSF level,improve therapeutic effect and shorten recovery time of signs of children with Mycoplasma pneumoniae,which has the value of clinical promotion.

关 键 词：小儿支原体肺炎 阿奇霉素 序贯治疗 C反应蛋白 粒细胞集落刺激因子 

分 类 号：R725.6[医药卫生—儿科]