川芎嗪注射液治疗重症肺炎合并慢性肾功能衰竭的疗效  

Effect of ligustrazine injection on severe pneumonia complicated with chronic renal failure

作　　者：于洋 YU Yang(Department of Internal Medicine,Fushun Occupational Disease Prevention and Treatment Hospital,Fushun 113001,China)

机构地区：[1]抚顺市职业病防治院内科,113001

出　　处：《中国实用医药》2021年第6期87-89,共3页China Practical Medicine

摘　　要：目的观察分析重症肺炎合并慢性肾功能衰竭采用川芎嗪注射液治疗效果。方法50例重症肺炎合并慢性肾功能衰竭患者,按照治疗方法不同分为对照组和观察组,每组25例。对照组采用呼吸内科治疗,观察组在对照组基础上采用川芎嗪注射液治疗。比较两组患者治疗前后各临床指标(心率、呼吸频率、平均动脉压、24 h尿量)、各症状(心率、喘止、呼吸衰竭纠正)恢复时间、治疗效果。结果治疗后,观察组患者心率(78.45±6.56)次/min、呼吸频率(17.23±3.87)次/min、平均动脉压(88.12±8.21)mm Hg(1 mm Hg=0.133 kPa)、24 h尿量(1211.31±58.90)ml,均优于对照组的(92.09±9.77)次/min、(28.09±5.56)次/min、(70.55±7.62)mm Hg、(765.42±50.78)ml,差异均具有统计学意义(P<0.05)。观察组患者心率恢复时间(6.79±1.22)d、喘止恢复时间(2.77±0.23)d、呼吸衰竭纠正时间(3.45±0.27)d均短于对照组的(9.78±1.55)、(6.12±1.30)、(7.12±1.11)d,差异均具有统计学意义(t=7.579、12.688、16.063,P<0.05)。观察组治疗总有效率88.0%高于对照组的64.0%,差异具有统计学意义(χ^(2)=3.947,P=0.047<0.05)。结论重症肺炎合并慢性肾功能衰竭在呼吸内科治疗基础上加入川芎嗪注射液治疗能够加快各症状缓解,改善各指标水平,提高治疗总有效率,临床效果较明显,因此值得推广采用。Objective To observe and analyze the effect of ligustrazine injection on severe pneumonia complicated with chronic renal failure.Methods A total of 50 cases of severe pneumonia complicated with chronic renal failure were divided into control group and observation group according to different treatment methods,with 25 cases in each group.The control group was treated with respiratory medicine,and the observation group was treated with ligustrazine injection on the basis of the control group.The recovery time of clinical indicators(heart rate,respiratory rate,mean arterial pressure,24-h urine output)and symptoms(heart rate,wheezing and respiratory failure)before and after treatment and therapeutic effect were compared between the two groups.Results After treatment,the heart rate(78.45±6.56)beats/min,respiratory rate(17.23±3.87)times/min,mean arterial pressure(88.12±8.21)mm Hg(1 mm Hg=0.133 kPa),24-h urine output(1211.31±58.90)ml of the observation group were all better than(92.09±9.77)beats/min,(28.09±5.56)times/min,(70.55±7.62)mm Hg and(765.42±50.78)ml of the control group,and the difference was statistically significant(P<0.05).The recovery time of heart rate,wheezing stop time and correction of respiratory failure of the observation group were(6.79±1.22),(2.77±0.23)and(3.45±0.27)d,which were all shorter than(9.78±1.55),(6.12±1.30)and(7.12±1.11)d of the control group,and the difference was statistically significant(t=7.579,12.688,16.063;P<0.05).The total effective rate of treatment 88.0%of the observation group was higher than 64.0%of the control group,and the difference was statistically significant(χ^(2)=3.947,P=0.047<0.05).Conclusion Ligustrazine injection based on respiratory medicine treatment has obvious clinical effect on patients with severe pneumonia combined with chronic renal failure,which can accelerate the relieve of symptoms,improve the level of indicators and the total effective rate of treatment.It is worthy of promotion and application.

关 键 词：呼吸内科治疗 川芎嗪注射液 重症肺炎 慢性肾功能衰竭 

分 类 号：R563.1[医药卫生—呼吸系统] R692.5[医药卫生—内科学]