犬流感病毒起源进化和宿主适应性机制研究进展  

Advances in Evolution Characterization and Host-Adaptation Mechanism of the Canine Influenza Virus

作　　者：李雪云 陈永坤 范颖 朱闻斐[2] 舒跃龙 LI Xueyun;CHEN Yongkun;FAN Ying;ZHU Wenfei;SHU Yuelong(School of Public Health(Shenzhen),Sun Yat-sen University,Guangzhou 510275,China;Chinese National Influenza Center,National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,WHO Collaborating Center for Referenceand Research on Influenza,Beijing 102206,China)

机构地区：[1]中山大学公共卫生学院(深圳),广州510275 [2]中国疾病预防控制中心病毒病预防控制所,国家流感中心,世界卫生组织流感参比和研究合作中心,北京102206

出　　处：《病毒学报》2021年第1期226-233,共8页Chinese Journal of Virology

基　　金：国家科技重大专项(项目号:2018ZX10305409-004-003),题目:广东省地区伴侣动物流感及冠状病毒等疾病传染源及传播风险研究。

摘　　要：甲型流感病毒的跨宿主传播一直是流感病毒研究的主要方向之一。犬作为人类主要的伴侣动物,其呼吸道组织也同时具有α-2,3禽流感病毒受体和α-2,6人流感病毒受体,是潜在的产生新型重配流感病毒的"基因混合器",在流感病毒的流行和跨宿主传播中扮演着重要角色。近年来,犬流感病毒已经在东南亚和美国等国家地区呈地区性流行,而且从犬中分离到了犬流感病毒与人流感病毒的重配株,因此犬流感病毒对公共卫生健康的潜在威胁不容忽视。本文将对犬流感病毒的流行、起源进化以及宿主适应性和致病性相关的分子机制进行综述,旨在为犬流感的防控和甲型流感病毒跨宿主传播研究提供参考。Cross-species transmission of influenza A viruses is an important research area.Dogs,as close companions of humans,carry SAα-2,3 Gal,and SAα-2,6 Gal receptors.In this way,dogs are considered to be"mixing vessels"for reassortments of influenza viruses.Dogs play an important part in the prevalence and cross-species transmission of influenza viruses.In recent years,canine influenza viruses(CIVs)have become endemic in Southeast Asia and the USA with the appearance of reassortment viruses between CIVs and influenza viruses from humans,which may pose a threat to public health.This is a review of CIVs focusing on their epizootiology,origin,evolution,molecular mechanisms on host adaption,and pathogenicity.Our review may provide a reference for the prevention and control of canine influenza and research on cross-species transmission of influenza A viruses.

关 键 词：犬 流感病毒 起源进化 宿主适应 

分 类 号：R183.3[医药卫生—流行病学]