关于脑心肌炎病毒2A蛋白的研究进展  

Research Progress in the 2A Protein of the Encephalomyocarditis Virus

作　　者：韩若婵 梁瑞英 杨增岐[2] 崔尚金[1] HAN Ruochan;LIANG Ruiying;YANG Zengqi;CUI Shangjin(Institute of Animal Sciences of CAAS,Chinese Academy of Agricultural Sciences,Beijing 100193,China;College of Veterinary Medicine,Northwest Agriculture and Forestry University,Yangling 712100,China)

机构地区：[1]中国农业科学院北京畜牧兽医研究所,北京100193 [2]西北农林科技大学动物医学院,杨陵712100

出　　处：《病毒学报》2021年第1期252-258,共7页Chinese Journal of Virology

基　　金：国家自然科学基金面上项目(项目号:31873019),题目:猪脑心肌炎病毒2A蛋白调控宿主细胞凋亡分子机制研究。

摘　　要：脑心肌炎病毒(Encephalomyocarditis virus,EMCV)是一种无囊膜的单股RNA病毒,属于小RNA病毒科,能够引起多种哺乳动物乃至人的感染。其非结构蛋白2A是重要的毒力因子,能够通过阻断翻译起始复合物的形成、结合翻译起始复合物因子及核糖体40s小亚基等方式竞争性地抑制宿主细胞蛋白的合成,还可通过抑制宿主细胞凋亡促进病毒扩散,并通过激活NF-κB引起宿主发生强烈的炎症反应[1]。此外,根据EMCV 2A蛋白的生物学特性,近年来,细胞生物学、病毒学领域均将其作为真核细胞与病毒互作的生物学工具展开了深入研究。The encephalomyocarditis virus(EMCV)is a single-stranded RNA virus without an envelope and belongs to the family Picornaviridae.It can cause several types of infection in mammals and humans.Nonstructural protein 2 A is an important virulence factor of the EMCV.It can competitively inhibit the synthesis of host cell proteins by blocking formation of the translation initiation complex,as well as acting on translation initiation complex factor and binding ribosome 40 S subunit.It can also promote virus proliferation by inhibiting apoptosis,and induce strong inflammation by activating the nuclear factor-kappa B pathway.Furthermore,according to the biological characteristics of 2 A protein,cytology and virology will use it for further research on eukaryotic cells and viruses.

关 键 词：脑心肌炎病毒(EMCV) 2A蛋白 细胞凋亡 毒力因子 致病作用 

分 类 号：R373.9[医药卫生—病原生物学]