桂枝茯苓联合宫瘤消胶囊预防子宫肌瘤剔除术后复发的临床研究  被引量:4

Clinical study of Guizhi Fuling combined with Gongliuxiao capsule in preventing recurrence after myomectomy

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作  者:陈晓芝 蔡洁娜 陈兰荭 张嘉乐 Chen Xiaozhi;Cai Jiena;Chen Lanpeng(The People's Hospital of Puning City,Puning,Guangdong 515300)

机构地区:[1]普宁市人民医院,广东普宁515300

出  处:《基层医学论坛》2021年第4期552-554,共3页The Medical Forum

基  金:广东省揭阳市卫生健康局立项(揭市卫【2020】64号)。

摘  要:目的探讨桂枝茯苓联合宫瘤消胶囊预防子宫肌瘤剔除术后复发的临床效果。方法选取2018年2月—2020年2月普宁市人民医院收治的子宫肌瘤患者220例作为研究对象,随机分为对照组55例、桂枝茯苓组55例、宫瘤消组55例、桂枝茯苓和宫瘤消胶囊组55例,4组患者均行腹腔镜下子宫肌瘤剔除术,对照组不服用任何药物,桂枝茯苓组患者服用桂枝茯苓,宫瘤消组患者服用宫瘤消,桂枝茯苓和宫瘤消组患者联合服用桂枝茯苓和宫瘤消。术后给药6个月后停药3个月,对4组患者的孕酮(P)、雌二醇(E2)、促黄体生成素(LH)、促卵泡生成素(FSH)等水平进行检测和对比,并记录子宫肌瘤复发情况。结果治疗前,4组患者P、E2、LH、FSH水平差异无统计学意义(P>0.05)。治疗后,桂枝茯苓和宫瘤消组患者血浆P、E2、LH、FSH激素水平均低于其他3组患者(P<0.05)。桂枝茯苓和宫瘤消组患者子宫肌瘤复发率低于其他3组患者(P<0.05)。桂枝茯苓和宫瘤消组治疗后复发患者的平均肌瘤体积小于其他3组复发患者(P<0.05)。结论桂枝茯苓与宫瘤消胶囊联合使用预防子宫肌瘤剔除术后复发的效果更加明显,有效改善各项性激素水平有关,值得推广。Objective To investigate the clinical effect of Guizhi Fuling combined with gongliuxiao capsule in preventing recurrence after myomectomy.Methods 220 patients with hysteromyoma admitted to Puning people's Hospital from February 2018 to February 2020 were selected as the research objects.They were randomly divided into control group(55 cases),Guizhi Fuling group(55 cases),gongliuxiao group(55 cases),Guizhi Fuling combined with gongliuxiao capsule group(55 cases).Four groups of patients were performed laparoscopic myomectomy,14 days after surgery according to different groups to take different drugs.The control group did not take any drugs;Guizhi Fuling group took Guizhi Fuling;gongliuxiao group took gongliuxiao;Guizhi Fuling and gongliuxiao groups used drugs according to the dose and cycle of the above four groups.The levels of progesterone(P),estradiol(E2),luteinizing hormone(LH)and follicle stimulating hormone(FSH)in the four groups were detected and compared,and the recurrence of uterine fibroids was recorded.Results After different intervention measures,the levels of P,E2,LH and FSH in the four groups were lower than those before treatment(P<0.05).Further comparison between groups showed that after treatment,the plasma levels of P,E2,LH and FSH in Guizhi Fuling and gongliuxiao groups were lower than those in the other three groups(P<0.05).The recurrence rate of hysteromyoma in Guizhi Fuling and gongliuxiao groups was lower than that in the other three groups(P<0.05).Although there was no significant difference in the average tumor volume between the four groups before treatment(P>0.05),the average tumor volume of recurrent patients in Guizhi Fuling and gongliuxiao groups was smaller than that in the other three groups(P<0.05).Conclusions Compared with gongliuxiao capsule alone,Guizhi Fuling combined with gongliuxiao capsule has more obvious effect on preventing recurrence after myomectomy.This is related to the improvement of sex hormone levels.The comprehensive therapy has certain clinical value and is worth

关 键 词:子宫肌瘤剔除术 复发 预防 桂枝茯苓 宫瘤消胶囊 

分 类 号:R2[医药卫生—中医学]

 

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