绝经后女性2型糖尿病患者发生骨质疏松性骨折的危险因素分析  

The risk factors of osteoporotic fracture in postmenopausal women with type 2 diabetes mellitus

作　　者：孟永久[1] 丁积勇[1] MENG Yong-jiu;DING Ji-yong(Department of Orthopedics,Shaoxing Hospital of Traditional Chinese Medicine,Shaoxing,Zhejiang 312000,China)

机构地区：[1]浙江省绍兴市中医院骨科,浙江绍兴312000

出　　处：《中国卫生检验杂志》2021年第1期98-100,共3页Chinese Journal of Health Laboratory Technology

基　　金：浙江省中医药科技计划项目(2019ZA125)。

摘　　要：目的探讨绝经后女性2型糖尿病(T2DM)患者发生骨质疏松性骨折的危险因素。方法采用回顾性研究方法,选取绝经后女性T2DM骨质疏松患者220例,根据有无骨折分为骨折组(n=100)和无骨折组(n=120),记录患者的一般资料,收集其空腹血样本用于血糖、血脂、尿酸、HbA_(1c)等检测。结果骨折组BMI、TG、FBG、HbA_(1c)水平高于无骨折组(P <0.05);Logistic回归分析提示,BMI、TG、FBG和HbA_(1c)是绝经后女性T2DM骨质疏松患者发生骨折的独立危险因素;分别根据BMI、TG、FBG和HbA_(1c)三分位数将绝经后女性T2DM骨质疏松患者分成3组,结果提示随着BMI、TG、FBG和HbA_(1c)水平的升高,骨折的发生率逐渐升高。结论在绝经后女性T2DM骨质疏松患者中,BMI、TG、FBG和HbA_(1c)是其发生骨折的独立危险因素。Objective To investigate the risk factors of osteoporotic fracture in postmenopausal women with type 2 diabetes mellitus( T2 DM). Methods A total of 300 postmenopausal women with T2 DM osteoporosis were divided in two groups according to the presence or absence of fracture: the fracture group( n = 100) and non-fracture group( n = 120). Anthropometric data was collected and glucose,lipid profile,uric acid and HbA_(1c)were determined in all patients. Results Compared with non-fracture group,patients in the fracture group had higher BMI,TG,FBG and HbA_(1c)( P < 0. 05). Logistic regressions analysis showed that BMI,TG,FBG and HbA_(1c)were independent risk factors for fracture in postmenopausal women with T2 DM osteoporosis. Postmenopausal women with T2 DM osteoporosis were divided into three groups according to BMI,TG,FBG and HbA_(1c)quartiles;the prevalence of fracture was increased by the elevated of BMI, TG, FBG and HbA_(1c)level.Conclusion BMI,TG,FBG and HbA_(1c)are independent risk factors for fracture in postmenopausal women with T2 DM osteoporosis.

关 键 词：2型糖尿病 骨质疏松性骨折 绝经 危险因素 

分 类 号：R587.1[医药卫生—内分泌]