广西某人群尿中多环芳烃代谢物与高血压1期的关系  

Association between Polycyclic Aromatic Hydrocarbon Metabolites in Urine and Stage 1 Hypertension in a Population of Guangxi Zhuang Autonomous Region

作　　者：黎丹妮 张丽娥[1] 杨洁 欧嵩凤 李志颖 冯宇梦 邹云锋[1] LI Danni;ZHANG Lie;YANG Jie;OU Songfeng;LI Zhiying;FENG Yumeng;ZOU Yunfeng

机构地区：[1]广西医科大学公共卫生学院,广西南宁530022

出　　处：《环境卫生学杂志》2020年第6期527-533,共7页JOURNAL OF ENVIRONMENTAL HYGIENE

基　　金：广西自然科学基金(2019GXNSFGA245002)。

摘　　要：目的探讨人群尿中单羟基多环芳烃代谢物(OH-PAHs)水平与高血压(HBP)1期的相关性。方法于2017年9月对广西河池某大型企业工人进行调查,在1608名参与调查者中,纳入作为研究对象共计429名。对上述研究开展问卷和健康体检,并收集其尿液;采用超高效液相色谱串联质谱仪(UPLC-MS/MS)对尿液中7种OH-PAHs进行检测分析。采用独立样本t检验和卡方检验对人群基线资料进行比较;采用Mann-Whitney U检验比较HBP 1期组和血压正常组人群尿中OH-PAHs水平;采用二元Logistic回归模型分析尿中OH-PAHs水平与人群HBP 1期的关联,并利用相乘模型分析年龄、BMI、饮酒、吸烟与OH-PAHs的交互作用。结果HBP 1期组和血压正常组人群在年龄、体质指数(BMI)、性别、饮酒情况方面差异具有统计学意义(P<0.01);7种尿OH-PAHs代谢物的检出率依次为:1-羟基萘(95.80%)、2-羟基萘(95.34%)、1-羟基芘(38.93%)、2-羟基芴(22.61%)、9-羟基芴(17.95%)、3-羟基芴(16.32%)和9-羟基菲(8.16%);在调整混杂因素后,Logistic回归分析结果显示,1-羟基萘高浓度组(Q4组,≥0.55μg/mmol肌酐)发生HBP 1期风险是参照组(Q1组,<0.10μg/mmol肌酐)的2.11倍(OR=2.11,95%CI:1.07~4.17,P<0.05)。结论人群尿中1-羟基萘水平升高可能是HBP 1期的危险因素。Objective To investigate the association of the urinary levels of monohydroxy polycyclic aromatic hydrocarbons(OH-PAHs)metabolites with stage 1 high blood pressure(HBP)in a population.Methods In September 2017,a questionnaire survey was performed among the workers from a large enterprise in Hechi,Guangxi and among 1608 workers participating in the investigation,429 were included as subjects.A questionnaire survey and physical examination were performed for these subjects,and their urine samples were collected.Ultra-performance liquid chromatography-tandem mass spectrometry was used to measure the concentrations of 7 kinds of OH-PAHs metabolites in urine.The independent samples t-test and the chi-square test were used to compare the baseline data of the population,and the Mann-Whitney U test was used to compare the urinary levels of OH-PAHs metabolites between the stage 1 HBP group and the normal blood pressure group;a binary logistic regression model was used to analyze the association between the levels of OH-PAHs in urine and stage 1 HBP in this population,and a multiplicative model was used to analyze the interactions of age,body mass index(BMI),drinking,smoking,and OH-PAH metabolites.Results There were significant differences in age,BMI,gender,and drinking between the stage 1 HBP group and the normal blood pressure groups(P<0.01).As for the 7 kinds of OH-PAH metabolites in urine,1-hydroxynaphthalene had the highest detection rate of 95.80%,followed by 2-hydroxynaphthalene(95.34%),1-hydroxypyrene(38.93%),2-hydroxyfluorene(22.61%),9-hydroxyfluorene(17.95%),3-hydroxyfluorene(16.32%)and 9-hydroxyphenanthrene(8.16%).After adjustment for confounding factors,the logistic regression analysis showed that the risk of stage 1 HBP in the high 1-hydroxynaphthalene group(Q4 group,≥0.55μg/mmol creatinine)was 2.11 times that in the control group(Q1 group,<0.10μg/mmol creatinine)(odds ratio=2.11,95%confidence interval:1.07~4.17,P<0.05).Conclusion The increase in the urinary level of 1-hydroxynaphthalene may be a risk fact

关 键 词：单羟基多环芳烃代谢物 羟基萘 高血压 关联 

分 类 号：R12[医药卫生—环境卫生学]