正交试验优选生津润燥合剂制备工艺  

Preparation Technology Optimization of Shengjinrunzao Mixture by Orthogonal Test

作　　者：卞振华 张文明 唐静月 费倩倩 袁晓航[1] 胡敏敏[1] 陈晓伟 冯子芳[1] 陆兔林[2] 费逸明 Bian Zhenhua;Zhang Wenming;Tang Jingyue;Fei Qianqian;Yuan Xiaohang;Hu Minmin;Chen Xiaowei;Feng Zifang;Lu Tulin;Fei Yiniing(Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Wuxi 214071,China;Nanjing University of Chinese Medicine)

机构地区：[1]南京中医药大学无锡附属医院,江苏无锡214071 [2]南京中医药大学

出　　处：《中国药师》2021年第1期152-155,共4页China Pharmacist

基　　金：国家自然科学基金项目(编号:81873008);无锡市科技发展资金项目(编号:N20192038);无锡市卫生健康委科研项目(编号:MS201941)。

摘　　要：目的:优选生津润燥合剂的制备工艺。方法:选取煎煮时间、加水量和煎煮次数为考察因素,以芍药苷转移率和浸膏得率为综合评价指标,采用正交试验法优选提取工艺;考察常压浓缩和减压浓缩对芍药苷含量的影响。结果:最佳提取工艺为加12倍量水,煎煮两次,每次1 h;常压和减压浓缩对合剂中芍药苷含量无显著影响。结论:该工艺合理稳定,可用于生津润燥合剂的生产。Objective: To optimize the preparation process of Shengjinrunzao mixture. Methods: The extraction process was optimized by orthogonal test with the content of peoniflorin and the yield of extract as the comprehensive evaluation index,and the decoction duration,decoction times and water addition amount as the influencing factors. The effects of atmospheric concentration and vacuum concentration on peoniflorin content were investigated. Results: The optimum extraction process was as follows: the herbs were with twice decoction with one hour for each time,and the added water amount was 12-fold of the herbs. Concentration at atmospheric or vacuum pressure had no significant effect on peoniflorin content in the mixture. Conclusion: The process is reasonably stable,and can be used for the production of Shengjinrunzao mixture.

关 键 词：提取工艺 正交试验 芍药苷 生津润燥合剂 

分 类 号：R283.6[医药卫生—中药学]