盐酸阿扎司琼注射液与注射用地塞米松磷酸钠的配伍相容性考察  

Compatibility of Dexamethasone Sodium Phosphate for Injection Combined with Azasetron Hydrochloride Injection

作　　者：杨金玉 雷凯 何光照[3] 刘雅楠 张程亮 刘东[1] 贺国芳 Yang Jinyu;Lei Kai;He Guangzhao;Liu Ya'nan;Zhang Chengliang;Liu Dong;He Guofang(Department of Pharmacy,Tongji Hospital Affiliated with Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Zhongnan Hospital of Wuhan University;Changzhou Fourth People's Hospital)

机构地区：[1]华中科技大学同济医学院附属同济医院,武汉430030 [2]武汉大学中南医院 [3]江苏省常州市第四人民医院

出　　处：《中国药师》2021年第2期394-398,共5页China Pharmacist

摘　　要：目的:考察盐酸阿扎司琼注射液和注射用地塞米松磷酸钠在输液中的配伍相容性。方法:在室温避光或不避光环境下,在0.9%氯化钠注射液输液袋中将临床常用量盐酸阿扎司琼与注射用地塞米松磷酸钠混合配伍,分别在0,3,6,24,48 h观察外观,测定不溶性微粒、p H、盐酸阿扎司琼和地塞米松磷酸钠的药物浓度。结果:上述配伍输液在48 h内均无浑浊、无变色、无沉淀和气体产生等,不溶性微粒符合规定标准,p H和两种药物浓度保持恒定。结论:在室温光照条件下,盐酸阿扎司琼注射液可以与注射用地塞米松磷酸钠在0.9%氯化钠注射液输液中配伍使用。Objective: To investigate the compatibility of dexamethasone sodium phosphate for injection and azasetron hydrochloride injection. Methods: With or without light at ambient temperature,dexamethasone sodium phosphate for injection and azasetron hydrochloride injection were dissolved in 0.9% sodium chloride infusion based on the practical concentration of clinical use. The appearance of solution was observed respectively at 0,3,6,24 and 48 h after the preparation,and the insoluble particle,p H value and contents of dexamethasone sodium phosphate and azasetron hydrochloride were also determined. Results: No turbidity,color change,precipitation and gas were shown in the mixed solution within 48 h. The number of insoluble particles met the relative requirement,and the p H value and drug contents were stable. Conclusion: At ambient temperature with light,dexamethasone sodium phosphate for injection and azasetron hydrochloride injection are compatible in 0.9% sodium chloride infusion.

关 键 词：盐酸阿扎司琼 地塞米松磷酸钠 配伍 稳定性 

分 类 号：R942[医药卫生—药剂学]