绝经后女性良性阵发性位置眩晕患者血清钙离子、维生素D及骨转换代谢指标研究  

Study on serum calcium ion,vitamin D and bone conversion and metabolism in postmenopausal women with benign paroxysmal positional vertigo

作　　者：尤孙文 孟盈盈[1] 叶晓红 康宗辉 陈孟权[1] 朱文宗[1] YOU Sun-wen;MENG Ying-ying;YE Xiao-hong;KANG Zong-hui;CHEN Meng-quan;ZHU Wen-zong(Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang University of Traditional Chinese Medicine,Wenzhou,Zhejiang 325000,China)

机构地区：[1]浙江省中医药大学附属温州市中医院,浙江温州325000

出　　处：《中国卫生检验杂志》2021年第2期199-202,共4页Chinese Journal of Health Laboratory Technology

基　　金：温州市科技局基金项目(Y20180706)。

摘　　要：目的探讨绝经后女性良性阵发性位置性眩晕(BPPV)患者血清钙离子、维生素D以及骨转换代谢相关指标的关系。方法选取2016年5月-2019年6月本院收治的绝经后BPPV患者180例为研究对象,依据骨密度分为正常骨密度组(47例)、骨密度减少组(54例)和骨质疏松组(79例),选择同期60例骨质疏松症(无眩晕)患者作为对照组,回顾分析各组间维生素D、血钙离子及骨转换代谢相关指标。结果骨质疏松组维生素D水平明显低于其他3组,尿脱氧吡啶啉(u-DPD)明显高于其他3组,骨钙蛋白明显高于正常骨密度组和骨密度减少组,差异均有统计学意义(P <0.05);多元回归分析显示骨质疏松与血清维生素D缺乏症是BPPV发生的危险因素(OR值分别为2.804、2.003,P <0.05)。结论骨质疏松、维生素D缺乏以及骨转换代谢指标与绝经后BPPV有关,临床需予以高度重视。Objective To investigate the relationship between serum calcium,vitamin D and bone turnover metabolism related indexes in postmenopausal women with benign paroxysmal positional vertigo(BPPV). Methods A total of 180 patients with postmenopausal BPPV treated in our hospital from May 2016 to June 2019 were selected as research subjects. They were divided into normal bone density group(47 cases),osteopenia group(54 cases) and osteoporosis group(79 cases) based on bone mineral density,and 60 cases of bone mass were selected during the same period. Patients with osteoporosis(no vertigo) were used as a control group,and retrospective analysis was performed on vitamin D,blood calcium ions and bone turnover metabolism related indexes between the groups. Results Vitamin D levels in the osteoporosis group were significantly lower than the other three groups,urinary deoxypyridoline(u-DPD) was significantly higher than the other three groups,and osteocalcin was significantly higher than the normal bone density group and the bone density reduction group,with the differences statistically significant(P < 0. 05). Multiple regression analysis showed that osteoporosis and serum vitamin D deficiency were risk factors for BPPV(OR = 2. 804,OR = 2. 003,P < 0. 05). Conclusion Osteoporosis,vitamin D deficiency,and bone turnover metabolites are related to postmenopausal BPPV,which should be highly valued in the clinic.

关 键 词：女性 良性阵发性位置性眩晕 骨质疏松 维生素D 骨转换代谢 

分 类 号：R764.3[医药卫生—耳鼻咽喉科]