血管紧张素转换酶2-血管紧张素(1-7)-Mas受体轴与高血压的相关性研究  

Relationship Between Angiotensin Converting Enzyme 2-Angiotensin(1-7)-Mas Receptor Axis and Hypertension

作　　者：张浩强 叶超 毛露 Dirk Hermann 陈艾东[1,3] ZHANG Haoqiang;YE Chao;MAO Lu;Dirk Hermann;CHEN Aidong(Key Laboratory of Targeting Interventions for Cardiovascular Diseases,Nanjing Medical University,Nanjing 211166,Jiangsu,China;Zhongda Hospital Affiliated to Southeast University,Nanjing 210096,Jiangsu,China;Center for Neurobiology,Duisburg-Essen University,Essen 45122,Germany)

机构地区：[1]南京医科大学心血管病靶向干预重点实验室,江苏南京211166 [2]东南大学附属中大医院,江苏南京210096 [3]杜伊斯堡-埃森大学神经生物学研究中心,德国埃森45122

出　　处：《心血管病学进展》2021年第2期141-143,共3页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金面上项目(31571168,81571246);国家公派留学基金(20173059);中国博士后基金(2016M591750,2017T100320)。

摘　　要：高血压发病率高,是全球范围内重大的慢性疾病,由它引发的心脑血管的并发症发病率和死亡率一直非常高。目前,本病的治疗效果不够理想,研究发现各种类型的高血压均有不同程度的肾素-血管紧张素系统过度增强现象,但其机制尚不清楚,其成为迫切需解决的重要科学问题。近期对血管紧张素转换酶2-血管紧张素(1-7)-Mas受体轴各成员及整个完整的肾素-血管紧张素系统深入研究和阐述,为治疗本病找到新的药物靶点提供了方向,现就此做一系统阐述。The high incidence of hypertension is a major chronic disease in the world.The morbidity and mortality of cardiovascular and cerebrovascular complications caused by hypertension are always very high.At present,the treatment effect of this disease is not ideal,studies have found that various types of hypertension have different degrees of excessive renin-angiotensin system(RAS)activity phenomenon,but the mechanism is not clear.This has become an important scientific problem that urgently needs to be solved.Recently,the members of angiotensin converting enzyme 2-angiotensin(1-7)-Mas receptor axis and the whole RAS have been deeply studied and elaborated,which provides directions for finding new drug targets for the treatment of this disease.This paper makes a systematic review for these.

关 键 词：血管紧张素转换酶2 血管紧张素(1-7) MAS受体 高血压 

分 类 号：R54[医药卫生—心血管疾病]