10772例患者抗核抗体谱检测结果的回顾性分析  

Retrospective analysis of the detection results of anti-nuclear antibody spectrum in 10772 patients

作　　者：秦妍妍[1] 杨延敏[1] QIN Yanyan;YANG Yanmin(Clinical Laboratory Department,Beijing Fengtai Hospital,Beijing 100070,China)

机构地区：[1]北京丰台医院检验科,北京100070

出　　处：《临床医学研究与实践》2021年第6期4-6,共3页Clinical Research and Practice

摘　　要：目的探讨抗核抗体(ANA)谱检测结果及筛查的意义。方法用免疫印迹法对10772例患者进行ANA谱检测,并对结果进行回顾性分析。结果10772例患者中,ANA谱阳性2671例,阳性率为24.8%。女性患者阳性率为27.7%,高于男性患者的21.0%(P<0.05)。总体ANA谱检测阳性率最高的前5项依次是抗Ro-52抗体(6.9%)、抗SSA抗体(4.6%)、抗AMA-M2抗体(3.6%)、抗组蛋白抗体(2.6%)、抗dsDNA抗体(2.2%);男性患者检测阳性率最高的前5项依次是抗Ro-52抗体(5.0%)、抗AMA-M2抗体(3.2%)、抗SSA抗体(2.7%)、抗组蛋白抗体(2.2%)、抗PM-Scl抗体(2.0%);女性患者检测阳性率最高的前5项依次是抗Ro-52抗体(8.4%)、抗SSA抗体(6.1%)、抗AMA-M2抗体(4.0%)、抗组蛋白抗体(3.0%)、抗CENP-B抗体(2.9%)。结论ANA谱存在一定的阳性率,在检测人群的性别上存在差异,临床诊疗过程中应进行ANA谱地筛查,以预防自身免疫性疾病(AID)漏诊情况的发生。Objective To explore the detection results and significance of screening of anti-nuclear antibody(ANA)spectrum.Methods The ANA spectrum of 10772 patients was detected by Western blotting method,and the results were analyzed retrospectively.Results Among the 10772 patients,2671 cases were ANA spectrum positive,the positive rate was 24.8%.The positive rate of female patients was 27.7%,which was higher than 21.0%of male patients(P<0.05).The top 5 items with the highest positive rate of the overall ANA spectrum test were anti-Ro-52 antibody(6.9%),anti-SSA antibody(4.6%),anti-AMA-M2 antibody(3.6%),anti-histone antibody(2.6%),and anti-dsDNA antibody(2.2%);the top 5 items with the highest positive rate in male patients were anti-Ro-52 antibody(5.0%),anti-AMA-M2 antibody(3.2%),anti-SSA antibody(2.7%),anti-histone antibody(2.2%),anti-PM-Scl antibody(2.0%);the top 5 items with the highest positive rate in female patients were anti-Ro-52 antibody(8.4%),anti-SSA antibody(6.1%),anti-AMA-M2 antibody(4.0%),anti-histone antibody(3.0%),anti-CENP-B antibody(2.9%).Conclusion There is a certain positive rate of ANA spectrum,and there are differences in the gender of the tested population.ANA spectrum screening should be carried out during clinical diagnosis and treatment to prevent missed diagnosis of autoimmune disease(AID).

关 键 词：抗核抗体谱 免疫印迹法 自身免疫性疾病 

分 类 号：R446[医药卫生—诊断学]