重庆地区90例新型冠状病毒肺炎患者的实验室检查特征分析  

Analysis of laboratory characteristics of 90 patients with Coronavirus Disease 2019 in Chongqing

作　　者：徐婷[1] 张晓丽 唐佳[1] 贺勇[1] 侯永彬[1] 曾猛 廖娟[2] 余莉华[1] XU Ting;ZHANG Xiaoli;TANG Jia;HE Yong;HOU Yongbin;ZENG Meng;LIAO Juan;YU Lihua(Department of Clinical laboratory,Yongchuan Hospital of Chongqing Medical University,Chongqing 402160,China;Department of Central laboratory,Yongchuan Hospital of Chongqing Medical University,Chongqing 402160,China)

机构地区：[1]重庆医科大学附属永川医院检验科,重庆402160 [2]重庆医科大学附属永川医院中心实验室,重庆402160

出　　处：《检验医学与临床》2021年第5期593-599,共7页Laboratory Medicine and Clinic

基　　金：重庆医科大学新型冠状病毒肺炎应急临床研究专项(批准号80);重庆市永川区自然科学基金项目(Ycstc.2020nb0201)。

摘　　要：目的探讨新型冠状病毒肺炎(COVID-19)患者的实验室检查结果及临床意义,以期为该病的临床诊疗和病情评估提供帮助。方法选取该院2020年1—3月90例COVID-19确诊患者纳为新冠肺炎组(根据病情又分为普通/轻型组、重/危重型组),同期就诊于发热门诊、排除COVID-19的70例流感样患者纳为发热门诊组,回顾性研究与分析患者临床资料和实验室检查结果。结果COVID-19各年龄段均有发病,首发症状不一。新冠肺炎组红细胞沉降率(ESR)、空腹血糖、乳酸脱氢酶(LDH)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)和血清铁蛋白(SF)水平高于发热门诊组,而白细胞计数、血红蛋白(Hb)、血小板计数、淋巴细胞计数(Lym)、单核细胞计数、中性粒细胞计数、总蛋白(TP)、清蛋白(ALB)、前清蛋白(PA)、尿素、尿酸、血清铁(sFe)和总铁结合力(TIBC)水平低于发热门诊组,差异均有统计学意义(P<0.05)。重/危重型组COVID-19患者C反应蛋白(CRP)、ESR、中性粒细胞百分比、LDH、α-羟丁酸脱氢酶和SF水平高于普通/轻型组患者,Hb、Lym、淋巴细胞百分比、TP、ALB、PA、TIBC水平低于普通/轻型组患者,差异均有统计学意义(P<0.05)。结论外周血中CRP、ESR、Lym、IgG、IgM、SF、sFe和TIBC水平的变化对COVID-19的诊疗和病情严重程度评估具有一定的参考价值。Objective To provide help for clinical diagnosis,treatment and evaluation of the condition by investigating the laboratory results and clinical significance of patients with Coronavirus Disease 2019(COVID-19).Methods A tatal of 90 cases with COVID-19 in the hospital from January to March 2020 were selected as the COVID-19 group(divided into the ordinary/mild group and the severe/critical group according to their condition),and 70 cases with influenza like symptoms who visited the fever clinic during the same period and excluded COVID-19 were included in the fever clinic group,the clinical data and laboratory examination results of the patients were studied and analyzed retrospectively.Results COVID-19 was found in all age groups with different initial symptoms.The levels of erythrocyte sedimentation rate(ESR),fasting blood glucose,lactate dehydrogenase(LDH),immunoglobulin G(IgG),immunoglobulin M(IgM)and serum ferritin(SF)in the COVID-19 group were higher than those in the fever clinic group,while the levels of white blood cell count,hemoglobin(Hb),platelet count,lymphocyte count(Lym),monocyte count,neutrophil count,total protein(TP),albumin(ALB),prealbumin(PA),urea,uric acid,serum iron(sFe)and total iron binding capacity(TIBC)were lower than those in the fever clinic group,and the differences were statistically significant Significance(P<0.05).The levels of C-reactive protein(CRP),ESR,neutrophil percentage,LDH,α-hydroxybutyrate dehydrogenase and SF in the severe/critical group were higher than those in the ordinary/mild group,while the levels of Hb,Lym,lymphocyte percentage,TP,ALB,PA and TIBC in the severe/critical group were lower than those in ordinary/mild group(P<0.05).Conclusion The changes in the levels of CRP,ESR,Lym,IgG,IgM,SF,sFe and TIBC in peripheral blood have certain reference value for the diagnosis and treatment of COVID-19 and the evaluation of the severity of the disease.

关 键 词：新型冠状病毒肺炎 实验室指标 临床分型 严重程度 

分 类 号：R512.99[医药卫生—内科学]