老年2型糖尿病患者颈内动脉粥样硬化斑块形成危险因素及对策分析  

Analysis on the risk factors and countermeasures of carotid atherosclerotic plaque formation in the elderly patients with type 2 diabetes

作　　者：林姝毓 应莲琴[1] 陈光[1] LIN Shuyu;YING Lianqin;CHEN Guang(Department of Vascular Surgery,Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University,Linhai,317000,China)

机构地区：[1]浙江省台州医院血管外科,浙江临海317000

出　　处：《中国现代医生》2021年第3期1-4,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2016KYA192)。

摘　　要：目的探讨老年2型糖尿病(T2DM)患者颈内动脉粥样硬化斑块(CASP)的发生率及其相关危险因素,为临床早期防治提供依据。方法选取2017年1月至2019年10月我院收治的254例T2DM患者作为研究对象,依据颈动脉内膜中层厚度是否>1.2 mm将其分为斑块组(n=105)和无斑块组(n=149)。采用多因素非条件Logistic回归分析确定T2DM患者CASP形成危险因素,并分析对策。结果老年T2DM患者CASP发生率为41.34%(105/254);多因素Logistic回归分析结果显示,年龄(OR=2.191)、糖尿病病程(OR=1.357)、高血压(OR=2.729)、DN(OR=3.333)、Hcy(OR=2.113)为老年T2DM患者CASP形成的危险因素,而肱踝指数(OR=0.349)为保护因素。结论老年T2DM患者具有较高的CASP发生率,针对这些独立高危因素,早期采取预防措施,降低CASP发生率,预防心脑血管疾病事件的发生。Objective To explore the incidence rate and related risk factors of internal carotid atherosclerotic plaque(CASP)in elderly patients with type 2 diabetes mellitus(T2DM),so as to provide a basis for early clinical prevention and treatment.Methods A total of 254 patients with T2DM who were admitted to our hospital from January 2017 to October 2019 were selected as the study subjects.According to whether the carotid intima-media thickness was greater than 1.2 mm,the patients were divided into plaque group(n=105)and non-plaque group(n=149).The multifactor unconditional Logistic regression was analyzed to determine the risk factors of CASP formation in T2DM patients,and the countermeasures were analyzed.Results The incidence rate of CASP in elderly T2DM patients was 41.34%(105/254);multivariate Logistic regression analysis showed that age(OR=2.191),duration of diabetes(OR=1.357),hypertension(OR=2.729),diabetic nephropathy(OR=3.333),and homocysteine(OR=2.113)were risk factors for the formation of CASP in elderly T2DM patients,while the brachial-ankle index(OR=0.349)was a protective factor.Conclusion Elderly T2DM patients have a higher incidence rate of CASP.In response to these independent high-risk factors,early preventive measures were taken to reduce the incidence rate of CASP and prevent the occurrence of cardiovascular and cerebrovascular events.

关 键 词：2型糖尿病 老年 颈内动脉粥样硬化斑块 危险因素 

分 类 号：R587.2[医药卫生—内分泌]