泵注比阿培南延长给药时间治疗ICU重症感染的临床效果  

Clinical efficacy on prolonged administration time of biapenem pump injection in the treatment of ICU severe infection

作　　者：李青[1] LI Qing(Department of Critical Care Medicine,the Second Affiliated Hospital of Fujian Traditional Chinese Medical University,Fuzhou350001,China)

机构地区：[1]福建中医药大学附属第二人民医院重症医学科,福建福州350001

出　　处：《中国现代医生》2021年第3期21-24,共4页China Modern Doctor

摘　　要：目的分析比阿培南延长给药时间后治疗ICU重症感染患者的临床效果。方法选取2018年2月至2019年12月于本院收治入住ICU的重症感染患者80例,随机分为对照组和实验组,每组各40例。对照组患者采用常规的比阿培南泵注时间进行治疗,实验组患者将延长比阿培南的泵注时间,并对两组患者的治疗效果、细菌总清除率、注射用药治疗时间、肝肾功能改善以及不良反应总发生率进行比较。结果治疗后实验组患者的总有效率明显高于对照组,差异有统计学意义(P<0.05)。实验组患者的细菌总清除率明显高于对照组,差异有统计学意义(P<0.05)。治疗后实验组患者的不良反应总发生率明显低于对照组,差异有统计学意义(P<0.05)。实验组患者注射用药治疗时间明显短于对照组,差异有统计学意义(P<0.05)。实验组患者ALT、AST、BUN水平均明显高于对照组,差异均有统计学意义(P<0.05)。结论将比阿培南给药时间延长治疗ICU重症感染患者效果显著,值得临床借鉴。Objective To carry out an experimental analysis on the clinical effect of prolonged administration time of biapenem for the patients with ICU severe infections.Methods A total of 80 severely infected patients who were admitted to the ICU in our hospital from February 2018 to December 2019 were selected and randomly divided into the control group and the experimental group.The control group was treated with routine biapenem pumping time,and the experimental group was treated with prolonged pumping time of biapenem.The therapeutic effect,total bacterial clearance rate,injection treatment time,improvement of liver and kidney function,and incidence rate of adverse reactions were compared between the two groups.Results The total rate of therapeutic effect in the experimental group after treatment was significantly higher than that in the control group,with significant difference(P<0.05).The total bacterial clearance rate in the experimental group was significantly higher than that in the control group,with significant difference(P<0.05).The total incidence rate of adverse reactions in the experimental group after treatment was significantly lower than that in the control group,with significant difference(P<0.05).The treatment time of injection in the experimental group was significantly shorter than that in the control group,with significant difference(P<0.05).The levels of ALT、AST、BUN in the experimental group were significantly higher than those in the control group,with significant difference(P<0.05).Conclusion Prolonging the administration time of biapenem in the treatment of patients with ICU severe infection is effective,and is worthy of clinical application.

关 键 词：比阿培南 延长给药时间 重症感染 临床效果 

分 类 号：R978.11[医药卫生—药品]