枯草杆菌二联活菌联合乳果糖治疗婴幼儿功能性便秘的临床疗效  

Clinical efficacy on treatment of infantile functional by live Bacillus Subtilis and Enterococcus Faecium combined with lactulose

作　　者：钱文文 眭颖 尹燕 QIAN Wenwen;SUI Ying;YIN Yan(Neonatology Department,Huzhou Maternal and Child Health Hospital in Zhejiang Province,Huzhou,313000,China;Department of General Surgery,Huzhou Maternal and Child Health Hospital in Zhejiang Province,Huzhou,313000,China)

机构地区：[1]浙江省湖州市妇幼保健院新生儿科,浙江湖州313000 [2]浙江省湖州市妇幼保健院普外科,浙江湖州313000

出　　处：《中国现代医生》2021年第3期67-69,73,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2018KY790)。

摘　　要：目的探讨枯草杆菌二联活菌联合乳果糖对婴幼儿功能性便秘(FC)的疗效。方法选取2018年2月至2019年2月我院治疗的FC患儿72例,随机分为治疗组和对照组,每组各36例。两组患儿均予改善不良饮食习惯、多饮水、进行适宜运动及锻炼其排便等基础治疗。治疗组加用枯草杆菌二联活菌联合乳果糖治疗,对照组加用枯草杆菌二联活菌治疗,两组均连续治疗6周。观察两组患儿起效时间、治疗效果、排便距离时间、排便费力消失时间。结果治疗组起效时间为(23.51±1.92)h,明显快于对照组的(29.72±2.21)h,差异有统计学意义(P<0.05)。治疗6周后,治疗组总有效率为88.9%,明显高于对照组的66.7%,差异有统计学意义(P<0.05)。治疗组的排便距离时间、排便费力消失时间短于对照组,差异有统计学意义(P<0.05)。结论枯草杆菌二联活菌联合乳果糖治疗婴幼儿FC的临床疗效较显著,能改善其粪便性质,且安全性较好,值得临床推广应用。Objective To investigate the efficacy of live Bacillus Subtilis and Enterococcus Faecium combined lactulose on functional constipation(FC)of infants.Methods From February 2018 to February 2019,a total of 72 children with FC treated in our hospital were selected and randomly divided into the treatment group(n=36)and the control group(n=36).Both groups of children were given basic treatment such as improving their bad eating habits,drinking more water,taking appropriate exercise and exercising their defecation.The treatment group was additionally treated with live Bacillus Subtilis and Enterococcus Faecium combined lactulose.The control group was given live Bacillus Subtilis and Enterococcus Faecium.The treatment in both groups were for 6 weeks.The onset time,therapeutic effect,defecation distance time and defecation effort disappearance time of the two groups of children were observed.Results The onset time(23.51±1.92)h of the treatment group was significantly faster than that of the control group(29.72±2.21)h,with statistical significance(P<0.05).After 6 weeks of treatment,the total effective rate of the treatment group was 88.9%,significantly better than 66.7%of the control group(P<0.05).The defecation distance time and defecation effort disappearance time in the treatment group were shorter than those in the control group,with an obvious difference and statistical significance(P<0.05).Conclusion Live Bacillus Subtilis and Enterococcus Faecium combined lactulose had significant clinical efficacy in the treatment of FC in infants.It significantly improved the fecal properties and had good safety,which were worthy of clinical promotion and application.

关 键 词：婴幼儿 枯草杆菌二联活菌 功能性便秘 乳果糖 

分 类 号：R725.7[医药卫生—儿科]