抗反转录病毒治疗依从性影响因素及改善方法研究进展  

Research progress on influencing factors and improvement methods of anti-retroviral therapy compliance

作　　者：王艳霞 周潞荣 王国平 WANG Yanxia;ZHOU Lurong;WANG Guoping(Department of Infectious Diseases,Changzhi Medical College,Changzhi046000,China;Department of Infectious Diseases,Changzhi People′s Hospital Affiliated to Changzhi Medical College,Changzhi046000,China)

机构地区：[1]长治医学院,山西长治046000 [2]长治医学院附属长治市人民医院感染科,山西长治046000

出　　处：《中国现代医生》2021年第3期188-192,共5页China Modern Doctor

摘　　要：人类免疫缺陷病毒(HIV)感染人体后会侵犯和破坏CD4+T细胞,破坏机体免疫功能,为重建或维持免疫功能,需要进行抗反转录病毒治疗(ART)。抗反转录病毒治疗通过使用抗反转录病毒药物抑制HIV复制,可以降低病毒载量和二次传播的风险,延长患者寿命,从而将艾滋病(AIDS)从一种终末期疾病变为另一种可控制的慢性疾病。抗反转录病毒治疗过程中,良好的依从性对抗反转录病毒药物疗效有重要影响,但是ART治疗依从性的影响因素有很多,涉及经济、社会、个人、生理、心理等方面。本文针对反转录病毒治疗依从性的影响因素和改善方法进行综述,以期为临床管理HIV患者提供参考。Human immunodeficiency virus(HIV)invades and destroys CD4+T cells after infecting the human body,destroying the body′s immune function.In order to rebuild or maintain immune function,anti-retroviral therapy(ART)is required.Anti-retroviral therapy uses anti-retroviral drugs to inhibit HIV replication,which can reduce the viral load and the risk of secondary transmission,prolong the life of patients,and thereby transform AIDS from an end-stage disease to a controllable chronic disease.Satisfactory compliance with anti-retroviral therapy has an important impact on the efficacy of anti-retroviral drugs.But there are many factors that affect the compliance of ART therapy,involving economic,social,personal,physical,and psychological aspects.This article will review the influencing factors and improvement methods of retroviral therapy compliance in order to provide references for the clinical management of HIV patients.

关 键 词：抗反转录病毒治疗 依从性 影响因素 改善方法 

分 类 号：R512.91[医药卫生—内科学]