生理药代动力学模型在天然药物药动学研究中的应用  

Application of Physiologically Based Pharmacokinetic(PBPK) Modeling in Pharmacokinetics of Natural Medicine

作　　者：姚莉 李思泽 李敏 丁宁[1] 相小强[1] Yao Li;Li Size;Li Min;Ding Ning;Xiang Xiaoqiang(School of Pharmacy,Fudan University,Shanghai 201203,China)

机构地区：[1]复旦大学药学院,上海201203

出　　处：《世界科学技术-中医药现代化》2020年第12期4147-4153,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委员会面上项目(81473409):PBPK建模预测CYP3A5基因型对五酯胶囊和他克莫司药动相互作用的影响,负责人:相小强;上海市科学技术委员会上海市2018年度“科技创新行动计划”实验动物研究领域项目(18140900900):生理药动学模型结合体外动态Bio-PK/PD系统替代大鼠进行药代动力学研究,负责人:相小强;国家科学技术部新药创制重大专项(2018ZX09711002-006-008):发展高效的糖修饰技术,构建糖苷类药物骨架库,负责人:丁宁。

摘　　要：生理药代动力学(Physiologically based pharmacokinetic,PBPK)模型是一种基于解剖生理学信息和药物的理化特征,模拟药物在体内各组织器官吸收、分布、代谢、消除过程的数学模型。本文就运用PBPK模型开展的天然药物药动学研究进行综述,从药物相互作用和特殊人群应用方面讨论了PBPK模型的应用与前景,旨在为天然药物的临床前研究和临床使用提供新思路。Physiologically based pharmacokinetic modeling is a kind of mathematics modeling technique that simulates the absorption, distribution, metabolism and elimination of drugs in various tissues and organs in vivo based on physiological and anatomical characteristics and physicochemical properties of drugs. This review summarizes the pharmacokinetic studies of natural medicine components using PBPK model and discusses the application and potential of PBPK modeling from the drug-drug interaction and application in special populations for natural medicine. This paper aims to provide a novel strategy for the preclinical research and clinical use of natural medicine.

关 键 词：生理药代动力学 天然药物 药物相互作用 特殊人群 

分 类 号：R285[医药卫生—中药学]