褪黑素及其受体介导的耳甲电刺激降糖效应机制研究进展及展望  

Melatonin and Its Receptors in the Antidiabetic Effect of Auricular Acupoints Stimulation

作　　者：李少源[1] 荣培晶[1] 高国建[2] 张紫璇 Li Shaoyuan;Rong Peijing;Gao Guojian;Zhang Zixuan(Institute of Acupuncture and Moxibustion,China Academy of Ch ineses Medical Sciences,Beijing 100700,China;Center of Traditional Chinese Medicine and Prevention of AIDS,China Academy of Chinese Medical Sciences,Beijing 100700,China.)

机构地区：[1]中国中医科学院针灸研究所,北京100700 [2]中国中医科学院中医药防治艾滋病研究中心,北京100700

出　　处：《世界科学技术-中医药现代化》2020年第12期4164-4168,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家科学技术部国家重点研发计划(2018YFC1705800):经皮颅-耳电刺激“调枢启神”抗抑郁临床方案优化及效应机制研究,负责人:荣培晶;国家自然科学基金委员会面上项目(81674072):耳甲电针调节糖耐量减低机制研究,负责人:荣培晶;国家自然科学基金委员会青年项目(82004181):褪黑素及其受体介导的耳迷走神经刺激降糖效应机制,负责人:李少源。

摘　　要：2型糖尿病发病率逐年攀升,给社会、家庭和个人都带来巨大负担。大量临床研究表明,耳针对高血糖状态具有明显的改善作用,且具有方便、简捷、利于操作等优势。由于2型糖尿病的发生与褪黑素的低水平密切相关,本文试图从褪黑素及其受体的角度进一步揭示耳甲电针降糖效应机制,为临床治疗糖尿病提供科学依据。The incidence of type 2 diabetes is increasing year by year, placing a huge burden on society, families and individuals. A large number of clinical studies have shown that electro-acupuncture on auricular region has a significant improvement effect on hyperglycemia, which has the advantages of convenience, simplicity and convenience for operation. Because the occurrence of type 2 diabetes is closely related to low level of melatonin, this study attempts to further reveal the hypoglycemic effect mechanism of electro-acupuncture on auricular region from the perspective of melatonin and its receptor, so as to provide a scientific basis for clinical treatment of type 2 diabetes.

关 键 词：耳甲电针 褪黑素 迷走神经 血糖 降糖 

分 类 号：R259[医药卫生—中西医结合]