化痰开痹汤对冠心病心绞痛(痰浊痹阻型)患者疗效及血脂、血清炎症因子水平的影响  

Effect of Huatan Kaibi Decoction on Patients with Coronary Heart Disease Angina Pectoris(Blockade of Phlegmturbidity Type) and the Level of Blood Lipid and Serum Inflammatory Factors

作　　者：韩景波[1] 吕艳杭 吴姗姗 王庆高[1] 雷贻禄[1] 苏博慧[1] 邢俊娥[1] 李海沅 Han Jingbo;Lv Yanhang;Wu Shanshan;Wang Qinggao;Lei Yilu;Su Bohui;Xing June;Li Haiyuan(First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China;Graduate School,Guangxi University of Chinese Medicine,banning 530222,China)

机构地区：[1]广西中医药大学第一附属医院,南宁530023 [2]广西中医药大学研究生学院,南宁530222

出　　处：《世界科学技术-中医药现代化》2020年第10期3696-3701,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：广西壮族自治区一流学科建设项目重点课题(2018XK070):桂枝法对冠心病患者流动条件下血小板粘附及血栓形成的影响及远期预后观察,负责人:王庆高;吴阶平医学基金会临床科研专项资助基金(320.6750.18226):心脑宁胶囊持续服药时间对冠心病患者流动条件下血小板粘附及血栓形成的影响及远期预后观察,负责人:王庆高;广西壮族自治区卫生适宜技术研究与开发项目(S201307-04):李锡光教授治疗冠心病临床经验应用,负责人:陈远平。

摘　　要：目的探讨化痰开痹汤对冠心病心绞痛患者血脂及炎症因子的影响和效果。方法将2017年2月-2019年2月确诊为冠心病心绞痛(痰浊痹阻型)患者100例随机分为2组,每组50例。对照组采用单纯常规西医综合治疗,治疗组在对照组的基础上加用化痰开痹汤。两组均治疗2个月后,观察治疗前后心绞痛症状、心电图、血脂[包括低密度脂蛋白(low density lipoprotein,LDL-C)、高密度脂蛋白(high density lipoprotein,HDL-C)、总胆固醇(total cholesterol,TG)、甘油三脂(triglyceride,TC)]、炎症因子[包括白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子(tumor necrosis factor,TNF-α)以及超敏C反应蛋白(hypersensitive C reaction,hs CRP)]等指标变化。结果两组患者治疗前心绞痛症状、心电图、血脂及炎症因子指标均无统计学差异(P>0.05);治疗后两组患者心绞痛症状、心电图均较治疗前改善(P<0.05),且治疗组改善程度较对照组显著(P<0.05);治疗后两组患者TC、TG、LDL-C较治疗前下降(P<0.05),HDL-C较治疗前升高(P<0.05),且治疗组变化程度较对照组显著(P<0.05);治疗后两组患者TNF-α、IL-6、hs CRP均较治疗前下降,且治疗组变化程度较对照组显著(P<0.05)。结论化痰开痹汤能明显改善冠心病心绞痛患者心绞痛疼痛的症状与持续时间,改善心电图情况、血脂水平及炎症因子水平,值得临床进一步研究。Objective To investigate the effect of Huatan kaibi Decoction on serum lipids and inflammatory factors in patients with coronary heart disease(CHD) angina pectoris. Methods A total of 100 patients diagnosed with coronary heart disease angina pectoris(phlegm turbid bi type) from February 2017 to February 2019 were randomly divided into 2 groups with 50 patients in each group. The control group was treated with conventional western medicine combined therapy, and the treatment group was added with Huatan Kaibi Decoction on the basis of the control group. Symptoms of angina pectoris, electrocardiogram, serum lipids including total cholesterol(TG), triglyceride(TC), low density lipoprotein(LDL-C), high density lipoprotein(HDL-C), and inflammatory factors including interleukin-6(IL-6), tumor necrosis factor(TNF-α) and Hypersensitive C reaction(hsCRP) were observed before and after the treatment for 2 months. Results Before treatment, there were no statistically significant differences in angina pectoris symptoms,electrocardiogram, blood lipids(TG, TC, HDL-C, LDL-C) and inflammatory factors(IL-6, TNF-α, hs-CRP) between the two groups(P >0.05). After treatment, angina pectoris symptoms and electrocardiogram in the two groups were improved compared with those before treatment(P< 0.05), and the degree of improvement in the treatment group was significantly higher than that in the control group(P< 0.05). After treatment, TC, TG and LDL-C in the two groups decreased compared with before(P< 0.05), while HDL-C increased(P< 0.05), and the change degree in the treatment group was significantly higher than that in the control group(P< 0.05). After treatment, TNF-α, IL-6 and hsCRP in both groups decreased compared with before treatment, and the change degree in the treatment group was significantly higher than that in the control group(P< 0.05). Conclusion Huatan Kaibi Decoction can significantly improve the symptoms and duration of angina pain, electrocardiogram performance, blood lipids and inflammatory factors of patients wi

关 键 词：化痰开痹汤 冠心病心绞痛 痰浊痹阻型 血脂 炎症因子 

分 类 号：R287[医药卫生—中药学]