血清可溶性尿激酶型纤溶酶原激活物受体在儿童下呼吸道感染中的表达及临床意义  

Expression and Clinical Significance of Serum Soluble Urokinase Type Plasminogen Activator Receptor in Children with Lower Respiratory Tract Infection

作　　者：姚欢迎 马兰[1] 郭平[1] 陈啸洪[1] Yao Huanying;Ma Lan;Guo Ping(Department of Pediatrics Shaoxing People′s Hospital Zhejiang Province,Shaoxing Hospital Zhejiang University,Zhejiang 312000,China)

机构地区：[1]绍兴市人民医院、浙江大学绍兴医院儿内科,312000

出　　处：《医学研究杂志》2021年第2期83-85,32,共4页Journal of Medical Research

基　　金：浙江省医药卫生一般研究计划项目(A类)(2015KYA219)。

摘　　要：目的通过检测血清可溶性尿激酶型纤溶酶原激活物受体(suPAR)表达水平变化,观察其对儿童下呼吸道感染(LTRIs)严重程度的评估价值。方法对162例LTRIs患儿(支气管肺炎84例,支气管炎78例)和88例对照组进行研究。研究对象入院后次日早晨空腹抽取静脉血4ml提取血清待测。采用ELISA法检测血清中suPAR水平,乳胶免疫比浊法检测血清CRP水平,循环增强荧光免疫法检测血清PCT水平。结果 LTRIs组血清suPAR、PCT、CRP水平明显高于对照组(P<0.01)。重度肺炎组患儿血清suPAR、CRP、PCT水平均高于轻度肺炎和支气管炎组患儿(P<0.01)。与支气管炎组比较,轻度肺炎组患儿血清suPAR水平显著升高(P<0.05),而血清CRP、PCT水平比较差异无统计学意义(P>0.05)。血清su-PAR、PCT和CRP预测肺炎患儿严重度的受试者工作特征曲线(ROC曲线)下面积(AUC)分别为0.962、0.837和0.703。结论 suPAR可以有效地反映儿童LTRIs的炎性反应状态,对肺炎预测的敏感度和重度肺炎的预测作用优于CRP和PCT。Objective To observe the value of serum soluble urokinase type plasminogen activator receptor(suPAR)expression in children with lower respiratory tract infection(LTRIs).Methods Totally 162 cases of LTRIs(84 cases of bronchopneumonia,78 cases of bronchitis)and 88 cases of control group were studied.The next morning after admission,4ml venous blood was drawn and serum was extracted for testing.The serum levels of suPAR,CRP and PCT were detected by ELISA,latex immunoturbidimetry and cyclic enhanced fluorescence immunoassay.Results The levels of serum suPAR,PCT and CRP in LTRIs group were significantly higher than those in control group(P<0.01).The levels of serum suPAR,CRP and PCT in severe pneumonia group were higher than those in mild pneumonia group and bronchitis group(P<0.01).Compared with bronchitis group,serum suPAR level in mild pneumonia group was significantly higher(P<0.05),while serum CRP and PCT levels had no significant difference(P>0.05).The area under receiver operating characteristic curve(ROC curve)of serum suPAR,PCT and CRP in predicting the severity of pneumonia in children were 0.962,0.837 and 0.703,respectively.Conclusion SuPAR can effectively reflect the inflammatory response of LTRIs in children,and the sensitivity of predicting pneumonia and the predictive effect of severe pneumonia are better than CRP and PCT.

关 键 词：可溶性尿激酶型纤溶酶原激活物受体 下呼吸道感染 预测价值 

分 类 号：R725.6[医药卫生—儿科]