轻度胃肠炎伴婴幼儿良性惊厥患儿血清γ干扰素、硫化氢水平变化及其临床意义  

Changes and clinical significance of serum IFN-γ and HS levels in children with benign infantile convulsion associated with mild gastroenteritis

作　　者：张玲[1] 屠友权[1] 方春艳[1] 黄明海[1] ZHANG Ling;TU You-quan;FANG Chun-yan;HUANG Ming-hai(Department of Pediatric Neurology,Women and Childrens Hospital in Ningbo,Ningbo,Zhejiang 315000,China)

机构地区：[1]宁波市妇女儿童医院小儿神经内科,浙江宁波315000

出　　处：《中华全科医学》2021年第2期252-255,共4页Chinese Journal of General Practice

基　　金：浙江省医药卫生项目(2020KY883)。

摘　　要：目的探究轻度胃肠炎伴婴幼儿良性惊厥(BICE)患儿血清γ干扰素(IFN-γ)、硫化氢(H2S)水平变化及临床意义,探究其在BICE的发生及疾病进展中的作用。方法以2017年3月—2019年7月在宁波市妇女儿童医院治疗的BICE患儿83例为观察组,并以同期健康体检者65例为对照组。分别采用ELISA法、分光光度法检测血清IFN-γ水平及H2S水平,分别采用Pearson检验、Spearman检验分析患儿血清IFN-γ、H2S水平及与病情严重程度的相关性;采用ROC曲线分析血清IFN-γ、H2S水平对BICE的诊断价值。结果观察组血清H2S、IFN-γ水平为(30.15±6.09)μmol/L、(5.68±1.13)μg/L,对照组为(43.28±8.34)μmol/L、(4.25±0.92)μg/L(t=11.066、8.277,均P<0.001);患儿血清IFN-γ水平与BICE的发病及病情严重程度呈正相关(P<0.05),而H2S水平与BICE的发病及病情严重程度呈负相关(P<0.05);血清IFN-γ、H2S水平诊断BICE的AUC为0.785、0.895。结论 BICE患儿血清IFN-γ、H2S水平与病情严重程度有关,且血清IFN-γ、H2S水平对BICE具有诊断价值。Objective To explore the changes and clinical significance of serum interferon-γ(IFN-γ) and hydrogen sulfide(H2S) levels in children with benign infantile convulsion associated with mild gastroenteritis(BICE), as well as to explore their roles in the occurrence and development of BICE. Methods A total of 83 BICE children who were treated in Women and Children’s Hospital in Ningbo from March 2017 to July 2019 were enrolled as observation group, whereas another 65 healthy controls during the same period were enrolled as control group. The levels of serum IFN-γ and H2S were detected by ELISA and spectrophotometry. The correlation between serum IFN-γ and H2S levels and the correlation between the two indices and severity of BICE were analysed by Pearson and Spearman tests. The diagnostic value of serum IFN-γ and H2S levels for BICE was analysed by ROC curves. Results The levels of serum H2S and IFN-γ in the observation group were significant different from those in the control group [(30.15±6.09) μmol/L,(5.68±1.13) μg/L vs.(43.28±8.34) μmol/L,(4.25±0.92) μg/L, t=11.066, 8.277, all P<0.001].They were also correlated with the severity of BICE(all P<0.05). The AUC values of serum IFN-γ and H2S levels for diagnosis of BICE were 0.785 and 0.895, respectively. Conclusion The levels of serum IFN-γ and H2S are relevant in BICE children and associated with disease severity. The serum IFN-γ and H2S levels are of diagnostic value for BICE.

关 键 词：轻度胃肠炎伴婴幼儿良性惊厥 干扰素Γ 硫化氢 病情严重程度 

分 类 号：R720.597[医药卫生—急诊医学] R446[医药卫生—儿科]