血清前列腺特异性抗原对良性前列腺增生患者前列腺体积的预测价值  

The predictive value of serum prostate-specific antigen on prostate volume in patients with benign prostatic hyperplasia

作　　者：周浩[1] 孙超[1] 李博[1] 关翰 陈志军[2] ZHOU Hao;SUN Chao;LI Bo;GUAN Han;CHEN Zhi-jun(Department of Urology,the Third People’s Hospital of Bengbu City,Bengbu,Anhui 233000,China;不详)

机构地区：[1]蚌埠市第三人民医院泌尿外科,安徽蚌埠233000 [2]蚌埠医学院第一附属医院泌尿外科,安徽蚌埠233004

出　　处：《中华全科医学》2021年第1期46-48,共3页Chinese Journal of General Practice

基　　金：安徽省教育厅重点项目(KJ2019A0355)。

摘　　要：目的通过分析血清总前列腺特异性抗原(total prostate specific antigen,tPSA)、游离前列腺特异性抗原(free prostate specific antigen,fPSA)、年龄与前列腺体积(prostate volume,PV)之间的关系,评估其预测前列腺体积的价值。方法整理2018年1月—2019年12月期间蚌埠市第三人民医院泌尿外科收治的111例前列腺增生患者的临床资料,所有患者均行前列腺电切术且病理证实为良性腺体增生。采用方差分析、LSD多重比较法分析不同年龄段的前列腺体积、tPSA、fPSA及不同前列腺体积的血清tPSA、fPSA的差异,进一步应用Pearson相关性分析描述患者年龄、tPSA、fPSA与PV之间的相关性,用于评估年龄、tPSA、fPSA预测PV的价值。结果3个年龄段之间的前列腺体积、tPSA、fPSA差异具有统计学意义(F=5.137,P=0.007;F=7.551,P=0.001;F=5.186,P=0.007),3个年龄段间两两比较后发现60~69岁组与70~79岁组和≥80岁组前列腺体积、tPSA、fPSA比较差异有统计学意义,但不同前列腺体积患者血清tPSA、fPSA值差异存在统计学意义(F=8.187,P<0.001;F=7.318,P=0.001),血清tPSA、fPSA值随前列腺体积增加而升高(均P<0.05)。患者的年龄、血清tPSA及血fPSA与PV呈正相关(r=0.259,P=0.006;r=0.375,P<0.001;r=0.339,P<0.001)。结论可以通过检测血清中的tPSA、fPSA水平预测PV,有利于判断良性前列腺增生(BPH)患者的病情发展程度、评估手术风险以及预后随访。Objective To evaluate the value of predicting prostate volume by analyzing the relationship between serum total prostate specific antigen(tPSA),free prostate specific antigen(fPSA),age and prostate volume(PV).Methods The clinical data of 111 patients with benign prostatic hyperplasia admitted to the Department of Urology,Bengbu Third People’s Hospital from January 2018 to December 2019 were compiled.All patients underwent prostatectomy and pathologically confirmed benign glandular hyperplasia.Variance analysis and LSD multiple comparison method were used to analyze the differences in prostate volume,tPSA,fPSA of different age groups,and the differences in serum tPSA and fPSA of different prostate volumes.Pearson correlation analysis was further used to describe the difference between patient age,tPSA,fPSA and PV,and evaluate the value of age,tPSA,and fPSA in predicting PV.Results The differences in prostate volume,tPSA,and fPSA among the three age groups were statistically significant(F=5.137,P=0.007;F=7.551,P=0.001;F=5.186,P=0.007).After pairwise comparison,it was found that prostate volume,tPSA,and fPSA were not completely statistically significant,but there were statistical differences in serum tPSA and fPSA values of prostate volumes of different sizes(F=8.187,P<0.001;F=7.318,P=0.001),the serum tPSA and fPSA values increased with the increase of the anterior gland volume(all P<0.05).The patient’s age,serum tPSA and blood fPSA were positively correlated with PV(r=0.259,P=0.006;r=0.375,P<0.001;r=0.339,P<0.001).Conclusion The detection of serum tPSA and fPSA levels can be used to predict PV,which is helpful for judging the degree of disease development of patients with benign prostatic hyperplasia(BPH),assessing surgical risk and prognostic follow-up.

关 键 词：前列腺增生 前列腺特异性抗原 前列腺体积 

分 类 号：R697.3[医药卫生—泌尿科学] R446[医药卫生—外科学]