环丁烯酮化合物高效合成喹啉衍生物的应用研究  

Study on the Efficient Synthesis of Quinoline Derivatives from Cyclobutenones

作　　者：付建平[1] 熊伟[1] 胡居吾[1] 韩晓丹[1] Fu Jianping;Xiong Wei;Hu Juwu;Han Xiaodan(Institute of Applied Chemistry,Jiangxi Academy of Sciences,Nanchang,330096)

机构地区：[1]江西省科学院应用化学研究所,南昌330096

出　　处：《化学通报》2021年第2期178-181,97,共5页Chemistry

基　　金：江西省重点研发计划项目(20192BBG70060);江西省杰出青年人才资助计划项目(20192BCB23027);江西省科学院重点科研项目(2017-YZD2-18)资助。

摘　　要：在酸催化作用下,成功实现了3-氨基-2-环丁烯酮开环重排一步合成喹啉类化合物,对反应溶剂、催化剂、温度、投料比等影响因素进行了考察,在优化反应条件下催化合成了一系列喹啉类化合物,获得了较好的产率。该合成方法具有反应温度低、产率高以及反应迅速等优点,为喹啉类衍生物的合成建立了一种简单有效的新方法。A series of quinoline derivatives were successfully obtained through opening-cyclization reaction of 3-amino-2-cyclobutanones in the presence of acid. By screening the reaction solvent, catalyst, temperature, feed ratio and other factors, the optimal reaction conditions were obtained. The method exhibits many advantages such as low temperature, high yield, rapid response and so on, and it establishes a simple and effective new method for the synthesis of quinoline derivatives.

关 键 词：环丁烯酮 开环反应 喹啉 

分 类 号：O626.323[理学—有机化学]