修复骨缺损的脂肪干细胞组织工程材料的研究进展  

Research progress of adipose stem cell tissue engineering materials for repairing bone defects

作　　者：赵鹏 黄东[3] 熊雅茹 刘晓春[3] 牟勇[3] 孙大炜[3] ZHAO Peng;HUANG Dong;XIONG Yaru;LIU Xiaochun;MOU Yong;SUN Dawei(University of South China,Hengyang,Hunan 421001,China;Department of Orthopedics,Kailuan General Hosptial,Tangshan,Hebei 063000,China;Department of Orthopedics,Second People's Hospital of Guangdong Province,Guangzhou,Guangdong 510000,China;Department of Anaesthesia,Second People's Hospital of Guangdong Province,Guangzhou,Guangdong 510000,China)

机构地区：[1]南华大学,湖南省衡阳市421001 [2]唐山开滦总医院骨科,河北省唐山市063000 [3]广东省第二人民医院创伤骨科,广东省广州市510000 [4]广东省第二人民医院麻醉科,广东省广州市510000

出　　处：《中南医学科学杂志》2021年第1期117-120,共4页Medical Science Journal of Central South China

基　　金：湖南省研究生创新项目(CX20190777)。

摘　　要：脂肪干细胞(ADSCs)作为组织工程材料中最为重要的种子细胞,被广泛应用于骨缺损修复的实验研究中。单独应用脂肪干细胞,因其自身成脂特性较强,无法满足骨缺损修复的需要,通过复合不同因子及生物技术而制成的组织工程材料可以很好的解决这一问题。目前以ADSCs为“种子细胞”的骨组织工程支架种类繁多,但尚无文章进行总结。因此,本文总结近年来中外研究所报道的此类骨组织工程支架,并对其优缺点进行深入总结,为今后临床骨缺损的治疗提供依据。Adipogenic mesenchymal stem cells(ADSCs),as the most important seed cells in tissue engineering materials,have been widely used in the experimental research of bone defect repair.ADSCs alone cannot meet the needs of bone defect repair due to their strong lipid formation.However,tissue engineering materials made by compounding different factors and biotechnology can solve this problem well.At present,there are many kinds of bone tissue engineering scaffolds using ADSCs as“seed cells”,but there is no paper to summarize.Therefore,this paper summarizes the recent reports of bone tissue engineering scaffolds reported by Chinese and foreign research institutes,and further summarizes their advantages and disadvantages,so as to provide a basis for the treatment of bone defect in the future.

关 键 词：骨缺损 脂肪干细胞 骨组织工程材料 

分 类 号：R34[医药卫生—基础医学]