育雏早期应用氟苯尼考对禽腺病毒感染雏鸡病情的影响  

Effects of application of florfenicol in early stage on condition of chickens infected with fowl adenovirus

作　　者：孟凡亮 刘蒙昊 宋一诺 张慧 李焱 曹龙龙 焦秋林 肖一红 刘思当 MENG Fanliang;LIU Menghao;SONG Yinuo;ZHANG Hui;LI Yan;CAO Longlong;JIAO Qiulin;XIAO Yihong;LIU Sidang(Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention/Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention,College of Animal Science and Veterinary Medicine,Shandong Agricultural University,Tai'an,Shandong 271018,China;College of Pharmaceutical Sciences,Wuhan University,Wuhan 430072,China)

机构地区：[1]山东农业大学动物科技学院,山东省动物生物工程与疾病防治重点实验室/山东省畜禽疫病防制工程技术研究中心,山东泰安271018 [2]武汉大学药学院,湖北武汉430072

出　　处：《中国兽医学报》2021年第2期332-337,共6页Chinese Journal of Veterinary Science

基　　金：山东省双一流奖补资金资助项目。

摘　　要：为了评价氟苯尼考的应用对禽腺病毒感染雏鸡病情的影响,本试验通过对血清4型禽腺病毒感染SPF雏鸡并应用氟苯尼考饮水给药,监测雏鸡的发病及排毒情况,并对免疫器官指数、干扰素相关基因及细胞因子基因表达情况进行检测。结果显示,病毒感染雏鸡后应用氟苯尼考能显著增加雏鸡的病死率及排毒量,加重雏鸡的病理学变化,并降低雏鸡免疫器官指数,还可降低干扰素相关基因IRF-7、2′-5′OAS、MX1和细胞因子基因IL-6、IFN-γ、TNF-α的转录水平。本试验进一步认识了氟苯尼考的毒副作用,对临床氟苯尼考的合理用药提供了相关数据支持,为进一步研究氟苯尼考的毒副作用奠定了基础。To evaluate the effect of florfenicol on the condition of chicks infected with fowl adenovirus,SPF chicks infected with fowl adenovirus serum type 4 were treated with florfenicol in this study.The incidence and detoxification were monitored,and the immune organ index,the expression of interferon-related genes and cytokine genes were detected.The results showed that florfenicol could significantly increase the mortality and excretion of virus,aggravate the pathological changes of chicks,and reduce the index of immune organs and the transcriptional level of interferon-related genes IRF-7,2′-5′OAS,MX1 and cytokine genes IL-6,IFN-γand TNF-α.This study further reveals the toxicity and side effects of florfenicol,provides relevant data support for the rational use of florfenicol in clinic,and lay a foundation for further study of the toxicity and side effects of florfenicol.

关 键 词：SPF雏鸡 氟苯尼考 禽腺病毒 病理变化 

分 类 号：S852.65[农业科学—基础兽医学] S859[农业科学—兽医学]