The impact of cannabinoid type 2 receptors(CB2Rs)in neuroprotection against neurological disorders  

作　　者：Qing Xin Fei Xu Devin HTaylor Jing-fu Zhao Jie Wu 

机构地区：[1]Institute of Brain Science and Diseases,and Department of Physiology,School of Basic Medicine,Qingdao University,Qingdao 266071,China [2]Institute of Neurobiology,Jining Medical University,Jining 272000,China [3]Department of Vascular Surgery,Jining No.1 People's Hospital,Jining 272000,China [4]Department of Biology,Utah Valley University,Orem,UT,USA

出　　处：《Acta Pharmacologica Sinica》2020年第12期1507-1518,共12页中国药理学报（英文版）

基　　金：The present work was supported by National Natural Science Foundation of China(81371437,81703490);Shandong Province Medical and Health Technology Development Project(No.2018WSB33004);Scientific Research Funds for young teachers of Jining Medical University(No.JYFC2019FKJ016);Research Fund for Academician Lin He New Medicine(JYHL2019MS17);Key Research and Development Project of Jining(2019SMNS018).

摘　　要：Cannabinoids have long been used for their psychotropic and possible medical properties of symptom relief.In the past few years,a vast literature shows that cannabinoids are neuroprotective under different pathological situations.Most of the effects of cannabinoids are mediated by the well-characterized cannabinoid receptors,the cannabinoid type 1 receptor(CB1R)and cannabinoid type 2 receptor(CB2R).Even though CB1Rs are highly expressed in the central nervous system(CNS),the adverse central side effects and the development of tolerance resulting from CB1R activation may ultimately limit the clinical utility of CB1R agonists.In contrast to the ubiquitous presence of CB1Rs,CB2Rs are less commonly expressed in the healthy CNS but highly upregulated in glial cells under neuropathological conditions.Experimental studies have provided robust evidence that CB2Rs seem to be involved in the modulation of different neurological disorders.In this paper,we summarize the current knowledge regarding the protective effects of CB2R activation against the development of neurological diseases and provide a perspective on the future of this field.A better understanding of the fundamental pharmacology of CB2R activation is essential for the development of clinical applications and the design of novel therapeutic strategies.

关 键 词：cann abinoid cann abinoid type 2 receptor n europrotecti on ischemic stroke Alzheimer's disease Parkins on disease 

分 类 号：R965[医药卫生—药理学]