独活寄生汤联合阿仑膦酸钠对骨质疏松症患者骨代谢指标、血液流变学以及血清炎症因子的影响  

Effect of Duhuojisheng Decoction Combined with Alendronate Sodium on Bone Metabolism, Hemorheology and Serum Inflammatory Factors in Patients with Osteoporosis

作　　者：杨帆 张静 俞烨晨 王娜娜[3] 陆乐 蔡辉 YANG Fan;ZHANG Jing;YU Ye-chen;WANG Na-na;LU Le;CAI Hui(Department of Integrated Traditional Chinese Medicine and Western Medicine,General Hospital of Eastern Theater of the Chinese People's Liberation Anny/Nanjing General Hospital of Nanjing Military Region,Nanjing,Jiangsu,210002,China;Department of Geriatrics,Nantong Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nantong,Jiangsu,226000,China;Department of General Medicine,Taizhou Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Taizhou,Jiangsu,225300,China)

机构地区：[1]中国人民解放军东部战区总医院/南京军区南京总医院中西医结合科,江苏南京210002 [2]南京中医药大学南通附属医院老年病科,江苏南通226000 [3]南京中医药大学泰州附属医院全科医学科,江苏泰州225300

出　　处：《现代生物医学进展》2020年第23期4501-4504,4509,共5页Progress in Modern Biomedicine

基　　金：国家中医药管理局重点专科(专病)建设项目(2007ZDZB001)。

摘　　要：目的:探讨独活寄生汤联合阿仑膦酸钠对骨质疏松症患者骨代谢指标、血液流变学以及血清炎症因子的影响。方法:选取于2017年5月~2019年12月期间我院收治的113例骨质疏松症患者,根据随机数表法将患者分为对照组(n=56)和研究组(n=57),对照组患者给予阿仑膦酸钠治疗,研究组在对照组的基础上联合独活寄生汤治疗,比较两组患者疗效、骨代谢指标、骨密度(BMD)、血液流变学以及血清炎症因子水平,记录两组治疗期间不良反应发生情况。结果:研究组治疗1个月后的临床总有效率为91.23%(52/57),高于对照组的76.79%(43/56)(P<0.05)。治疗1个月后两组BMD、血清碱性磷酸酶(ALP)升高,且研究组较对照组高(P<0.05);两组治疗1个月后血清磷(S-P)、血清钙(S-Ca)组间比较无差异(P>0.05)。治疗1个月后两组全血黏度低切、白介素-6(IL-6)、纤维蛋白原、肿瘤坏死因子-α(TNF-α)、全血黏度高切、白介素-1(IL-1)下降,且研究组低于对照组(P<0.05)。两组不良反应发生率比较无差异(P>0.05)。结论:骨质疏松症患者采用独活寄生汤联合阿仑膦酸钠治疗,疗效确切,可有效改善骨代谢、血液流变学以及血清炎症因子水平,且不增加不良反应发生率。Objective: To investigate the effect of Duhuojisheng decoction combined with alendronate sodium on bone metabolism, hemorheology and serum inflammatory factors in patients with osteoporosis. Methods: 113 patients with osteoporosis in our hospital from May 2017 to December 2019 were selected, they were divided into control group(n=56) and study group(n=57) according to the method of random number table. Patients in the control group were treated with alendronate sodium. The study group was treated with Duhuojisheng decoction on the basis of the control group. The curative effect, bone metabolism index, bone density(BMD) and hemorheology and serum inflammatory factors of the two groups were compared. The adverse reactions of the two groups were recorded.Results: The total clinical effective rate of the study group at 1 month after treatment was 91.23%(52/57), which was higher than 76.79%(43/56) of the control group(P<0.05). 1 month after treatment, BMD, serum alkaline phosphatase(ALP) of the two groups increased, and the study group was higher than the control group(P<0.05). There were no significant differences between the two groups at 1 month after treatment in serum phosphorus(S-P) and serum calcium(S-Ca)(P>0.05). 1 month after treatment, low whole blood viscosity,interleukin-6(IL-6), fibrinogen, tumor necrosis factor-α(TNF-α), high whole blood viscosity and interleukin-1(IL-1) of the two groups decreased, and the study group was lower than the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Duhuojisheng decoction combined with alendronate sodium is effective in the treatment of osteoporosis. It can effectively improve bone metabolism, hemorheology and serum inflammatory factors, and does not increase the incidence of adverse reactions.

关 键 词：独活寄生汤 阿仑膦酸钠 骨质疏松症 骨代谢 血液流变学 炎症因子 

分 类 号：R68[医药卫生—骨科学]