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作 者:郑艳妮[1] 贺芬[1] 沙海旺[1] 张旭 袁伟伟[1] ZHENG Yan-ni;HE Fen;SHA Hai-wang;ZHANG Xu;YUAN Wei-wei(Surgical Intensive Care Center,Affiliated Hospital of Yan'an University,Yan'an,Shaanxi,716000,China)
机构地区:[1]延安大学附属医院外科重症监护中心,陕西延安716000
出 处:《现代生物医学进展》2020年第23期4561-4564,4592,共5页Progress in Modern Biomedicine
基 金:国家自然科学基金项目(81760069);陕西省社会发展科技攻关项目(2016SF-075)。
摘 要:目的:研究血必净注射液联合比阿培南对重症肺炎患者肺功能的影响。方法:选择2017年1月~2019年12月我院的103例重症肺炎患者,随机分为两组。对照组静脉滴注比阿培南0.3 g,每8 h给药1次;观察组联合静脉滴注血必净50 mL,每天两次。检测两组的炎症因子:白介素-1(Interleukin-1,IL-1)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)和IL-6水平,应激激素:皮质醇(Cortisol,Cor)、人血管紧张素Ⅰ(Human angiotensin I,AngⅠ)、去甲肾上腺素(Noradrenaline,NE)和人血管紧张素Ⅱ(Human angiotensinⅡ,AngⅡ)水平,肺功能:第一秒最大呼气量(Maximum expiratory volume in the first second,FEV1)、FEV1%pred、用力肺活量(Forced vital capacity,FVC)。结果:观察组的有效率明显高于对照组(P<0.05)。治疗后,两组的血清IL-1、TNF-α、IL-6、Cor、AngⅠ、NE和AngⅡ水平水平均明显降低,FEV1、FEV1%pred和FEV1/FVC明显升高(P<0.05),且观察组的上述指标明显优于对照组(P<0.05)。结论:血必净注射液联合比阿培南对重症肺炎有显著的疗效,不但能明显改善肺功能,还能有效抑制患者的应激反应和炎症反应,值得推广。Objective: To investigate the effect of Xuebijing injection combined with biapenem on pulmonary function in patients with severe pneumonia. Methods: Selected 103 cases of patients with severe pneumonia who were treated in our hospital from January 2017 to December 2019, divided into two groups randomly. The control group received 0.3 g of apenem once every 8 hours, while the observation group received 50 m L of Xuebijing twice a day. Detection of inflammatory factors in two groups: interleukin-1(IL-1), tumor necrosis factor-α(TNF-α) and IL-6 levels, stress hormone: Cortisol(Cor), human angiotensin I(Ang I), norepinephrine(NE) and human angiotensin II(Ang II) levels, lung function: maximum expiratory volume in the first second(FEV1), FEV1%pred, Forced vital capacity(FVC). Results: The effective rate of the observation group was significantly higher than control group(P<0.05). After treatment, the levels of serum IL-1, TNF-α, IL-6, Cor, AngⅠ, NE and AngⅡof the two groups were significantly reduced, and FEV1, FEV1%pred and FEV1/FVC were significantly increased(P<0.05), and the above indicators of the observation group were significantly better than the control group(P<0.05). Conclusion: Xuebijing injection combined with biapenem has a significant effect on severe pneumonia. It can not only improve the lung function, but also effectively inhibit the stress response and inflammatory response of patients. It is worth popularizing.
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