胆固醇酯转移蛋白活性水平的性别差异及与心血管病危险因素关系的研究  

Gender-specific difference in cholestery ester transfer protein activity and its association with known cardiovascμLar risk factors

作　　者：李皓炜 赵冬[1] 刘静[1] 王淼[1] 孙佳艺[1] 刘军[1] 李岩[1] 邓秋菊 齐玥[1] LI Haowei;ZHAO Dong;LIU Jing;WANG Miao;SUN Jiayi;LIU Jun;LI Yan;DENG Qiuju;QI Yue(Department of Epidemiology,Beijing Anzhen Hospital,Capital Medical University,Beijing Institute of Heart,Lung and Blood Vessel Diseases,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所流行病研究室

出　　处：《心肺血管病杂志》2021年第1期1-5,共5页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：目的:探讨胆固醇酯转移蛋白(CETP)活性水平的性别差异及其与心血管病危险因素的关系。方法:以参加"中国多省市心血管病队列研究"2002年危险因素调查的,北京地区45~74岁队列人群中资料完整的1350人(男性627人,女性723人)作为研究对象。CETP活性水平采用荧光法测定。对男女两性的CETP活性水平以及CETP活性与危险因素的关系进行分析。结果:总人群中CETP活性水平为83.19(66.25~103.58)pmol·μL^(-1)·h^(-1),女性高于男性[86.44(69.56~106.75)vs.79.91(62.78~100.29)pmol·μL^(-1)·h^(-1),P=0.001]。(2)男性年龄、血压以及饮酒、超重和高血压患病率高于女性,而女性的TG、HDL-C高于男性。(3)相关分析显示,男女两性的CETP活性与BMI、血脂(TG、HDL-C)及hs-CRP均相关(P<0.01)。女性CETP活性与LDL-C水平呈负相关(P=0.014),而男性CETP活性与载脂蛋白B-100呈正相关(P=0.010)。(4)多因素Logistic回归分析显示,在调整年龄、BMI、收缩压、LDL-C、HDL-C、TG、FBG、hs-CRP、吸烟、饮酒、服用降脂药后,女性CETP活性水平仍高于男性(OR=1.863,95%CI:1.354~2.563,P=0.001)。结论:女性CETP活性水平高于男性,性别对CETP活性水平可能具有独立影响。Objective:This study was designed to explore the gender-specific difference in cholestery ester transfer protein(CETP)activity and its association with known cardiovascular risk factors.Methods:Participants in this study were recruited from the Beijing project in the Chinese multi-provincial cohort study(CMCS).A total of 1350 participants with complete data were finally included,with 627 males and 723 females.CETP activity was determined by the BioVision’s CETP Activity Fluorometric Assay Kit.Analysis was done on the difference in CETP activity between genders and its association with known cardiovascular risk factors.Results:The CETP activity in the total participants was 83.19(66.25-103.58)pmol·μL^(-1)·h^(-1),and it was higher in females than in males[86.44(69.56-106.75)vs.79.91(62.78-100.29)pmol·μL^(-1)·h-1,P=0.001].(2)The age,blood pressure,alcohol,overweight,and prevalence of hypertension are higher in males,while TC and HDL-C are higher in females.(3)Correlation analysis showed that CETP activity was positively correlated with BMI,triglycerides,hs-CRP,and negatively correlated with HDL-C in both genders(P<0.01).The CETP activity was negative correlated with LDL-C in females,yet positively correlated with apolipoprotein B-100 in males(P<0.05).(4)After adjustment for age,BMI,SBP,LDL-C,HDL-C,triglycerides,blood glucose,hs-CRP,smoking,drinking,and lipid-lowering drugs in a multiple logistic regression model,CETP activity was still significantly higher in females than in males(OR=1.863,95%CI:1.354-2.563,P=0.001).Conclusions:CETP activity was higher in females than in males.But this gender-specific difference cannot be fully explained by the gender difference of the major cardiovascular risk factors.

关 键 词：胆固醇酯转移蛋白 性别因素 心血管疾病 危险因素 

分 类 号：R54[医药卫生—心血管疾病]