黄斑区形态改变在糖尿病视网膜病变早期诊断中的价值  

Value of macular morphological changes in early diagnosis of diabetic retinopathy

作　　者：李婷婷[1] 牛彤彤[1] 吕婷婷 陈思文 LI Tingting;NIU Tongtong;LV Tingting;CHEN Siwen(Department of Ophthalmology,Shenyang Fourth People's Hospital,Shenyang 110000,China)

机构地区：[1]沈阳市第四人民医院眼科,辽宁沈阳110000

出　　处：《分子影像学杂志》2021年第1期159-162,共4页Journal of Molecular Imaging

摘　　要：目的探讨黄斑区形态改变在糖尿病视网膜病变(DR)早期诊断中的价值。方法选取2018年1月~2019年6月在我院治疗的2型DR患者108例,其中非增殖性DR(NPDR组)68例,增殖性DR(PDR组)40例,同时选取单纯2型糖尿病患者50例作为对照,各组均行光学相干断层扫描血流成像(OCTA)检查,比较各组黄斑区血流密度(MVD)、黄斑中心凹无血管区(FAZ)及黄斑视网膜厚度差异。结果NPDR组和PDR组黄斑区MVD分别为(0.48±0.02)%和(0.47±0.03)%,低于对照组(P<0.05);NPDR组和PDR组FAZ竖径分别为0.37±0.03 mm和0.38±0.02 mm,高于对照组(P<0.05);PDR组FAZ面积为0.49±0.04 mm^2,高于对照组和NPDR组(P<0.05);对照组、NPDR组和PDR组黄斑区平均视网膜厚度的差异无统计学意义(P>0.05);黄斑区MVD、FAZ竖径、FAZ面积诊断NPDR和PDR的ROC曲线下面积分别为0.845、0.840和0.922(P<0.05),截断值分别为0.50%、0.37 mm和0.43 mm^2,敏感度分别为80.50%、79.80%和88.50%,特异性分别为78.00%、75.00%和84.00%。结论DR患者黄斑区MVD降低,而FAZ竖径及面积扩大,在诊断中有一定应用价值。Objective To investigate the value of macular morphological changes in the early diagnosis of diabetic retinopathy(DR).Methods A total of 108 patients with type 2 DR treated in our hospital from January 2018 to June 2019 were selected.There were 68 cases of non proliferative DR(NPDR group),40 cases of proliferative DR(PDR group)and 50 cases of simple type 2 diabetes mellitus(DM group).The optical coherence tomography blood flow imaging(OCTA)was performed in each group,the blood flow density(MVD),macular fovea avascular area(FAZ)and macular retinal thickness were compared among the groups.Results The MVD of macular area in NPDR group and PDR group were(0.48±0.02)%and(0.47±0.03)%,which were significantly lower than those in DM group(P<0.05).The vertical diameter of FAZ in NPDR group and PDR group were 0.37±0.03 mm and 0.38±0.02 mm respectively,which were significantly higher than those in DM group(P<0.05).The area of FAZ in PDR group was 0.49±0.04 mm^2,which was significantly higher than that in DM group and NPDR group(P<0.05).There was no significant difference of mean macular retinal thickness between DM group,NPDR group and PDR group(P>0.05).The area under ROC curve of MVD,FAZ vertical diameter and FAZ area in the diagnosis of NPDR and PDR were 0.845,0.840 and 0.922,respectively(P<0.05).The cut-off values were 0.50%,0.37 mm and 0.43 mm^2,respectively.The sensitivity were 80.50%,79.80%and 88.50%,and the specificity were 78.00%,75.00%and 84.00%,respectively.Conclusion In DR patients,the MVD of macular area decreases,while the vertical diameter and area of FAZ are enlarged,which has certain application value in the diagnosis.

关 键 词：糖尿病视网膜病变 黄斑区 光学相干断层扫描血流成像 诊断价值 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]