老年人心肌细胞自噬的变化及其调控机制研究进展  

Advances in research on altered cardiomyocyte autophagy and its regulatory mechanisms in the elderly

作　　者：杨利国[1] 赵惠萍[1] 李保[1] 秦富忠 Yang Liguo;Zhao Huiping;Li Bao;Qin Fuzhong(Department of Cardiovascular Medicine,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第二医院心血管内科,太原030001

出　　处：《中华老年医学杂志》2021年第2期265-268,共4页Chinese Journal of Geriatrics

基　　金：国家自然科学基金(81470526、81670369、81870214)。

摘　　要：心肌细胞自噬对维持正常心脏结构和功能起重要作用。近年来的研究结果表明老年人心肌细胞自噬功能降低,老年人心肌自噬基因Atg5、Atg7和Beclin1表达降低;心肌细胞自噬下调与磷脂酰肌醇3-激酶/丝氨酸-苏氨酸激酶/雷帕霉素靶蛋白和单磷酸腺苷激活的蛋白激酶及SIRT1信号通路失调有关;此外,活性氧及一些神经内分泌因子也可介导老年人心肌细胞自噬下调。调控心肌细胞自噬将为老年人心肌病的预防和治疗提供新的途径。Cardiomyocyte autophagy plays an important role in maintaining normal cardiac structure and function.Recent studies have shown that cardiomyocyte autophagy is decreased in the aging heart.The expression of autophagy-related genes Atg5,Atg7 and Beclin1 decreases in the aging myocardium.Decreased cardiomyocyte autophagy in the aging heart is associated with dysregulation of phosphatidylinositol-3-kinase(PI3K)/serine-threonine kinase(Akt)/mammalian target of rapamycin(mTOR),adenosine monophosphate-activated protein kinase(AMPK)and/or the SIRT1 signaling pathways.In addition,reactive oxygen species and some neural hormonal factors such as endothelin-1 can also mediate the decrease of cardiomyocyte autophagy in cardiac aging.The regulation of cardiomyocyte autophagy may provide new strategies for the prevention and treatment of cardiomyopathy in the elderly.

关 键 词：自噬 肌细胞 心脏 细胞衰老 

分 类 号：R542.2[医药卫生—心血管疾病]