抗逆转录病毒治疗对艾滋病患者脑灰质体积的影响  

Effects of Antiretroviral Therapy on Brain Gray Matter Volumes in AIDS Patients

作　　者：辛红涛 吴光耀[2,3] 文之 雷皓[1,5] 林富春 XIN Hong-tao;WU Guang-yao;WEN Zhi;LEI Hao;LIN Fu-chun(State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics,National Center for Magnetic Resonance in Wuhan(Wuhan Institute of Physics and Mathematics,Innovation Academy for Precision Measurement Science and Technology,Chinese Academy of Sciences),Wuhan 430071,China;Department of Radiology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Department of Medical Imaging,Shenzhen University General Hospital,Medical College of Shenzhen University,Shenzhen 518055,China;Department of Radiology,Renmin Hospital of Wuhan University,Wuhan 430060,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]波谱与原子分子物理国家重点实验室,武汉磁共振中心(中国科学院精密测量科学与技术创新研究院武汉物理与数学研究所),湖北武汉430071 [2]武汉大学中南医院放射科,湖北武汉430071 [3]深圳大学总医院医学影像科,深圳大学医学院,广东深圳518055 [4]武汉大学人民医院放射科,湖北武汉430060 [5]中国科学院大学,北京100049

出　　处：《波谱学杂志》2021年第1期69-79,共11页Chinese Journal of Magnetic Resonance

基　　金：国家自然科学基金资助项目(81171315,81571757).

摘　　要：磁共振影像学研究表明艾滋病患者的脑结构发生了变化.虽然联合抗逆转录病毒治疗(combined antiretroviraltherapy,cART)能提高艾滋病患者的长期生存率,但是cART对艾滋病患者脑结构改变的影响并不清楚.本研究利用三维高分辨脑结构磁共振成像(magnetic resonance imaging,MRI)技术,使用基于体素的形态测量学方法,探讨了cART对艾滋病患者脑灰质体积的影响.本研究表明cART可以有效减少艾滋病患者的异常脑结构,提示早期实施cART的重要性.Magnetic resonance imaging(MRI)studies have documented that there were structural abnormalities in acquired immune deficiency syndrome(AIDS)patients.Although the long-term survival rate of AIDS patients can be improved by the combined antiretroviral therapy(cART),little is known about the effect of cART on brain structural alterations in AIDS patients.In this study,three-dimensional high-resolution brain structure MRI and voxel-based morphometric methods were used to explore the effects of cART on brain gray matter volume in AIDS patients.The results indicate that cART may effectively mitigate the occurrence of abnormal brain structure in AIDS patients,emphasizing the importance of early initiation of cART.

关 键 词：磁共振成像(MRI) 艾滋病 联合抗逆转录病毒治疗(cART) 灰质体积 

分 类 号：O482.53[理学—固体物理]