长骨骨缺损的组织工程治疗现状  

Current status of tissue engineering therapy on long bone defects

作　　者：黄希(综述) 王文波(审校)[1] HUANG Xi;WANG Wenbo(Third Department of Orthopedics,First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院骨三科,哈尔滨150001

出　　处：《临床与病理杂志》2021年第2期456-461,共6页Journal of Clinical and Pathological Research

基　　金：黑龙江省自然科学基金(H201454);黑龙江省普通高等学校骨干教师创新能力资助计划(1054G028)。

摘　　要：临床中长骨骨缺损一直是骨外科治疗的挑战,通常由开放骨折后骨缺损、骨肿瘤切除骨段、慢性骨髓炎去除死骨等因素导致。尤其是长骨大段骨缺损,除了大段的骨缺损外常伴有软组织状况不佳或感染倾向。目前国内外治疗手段多样,骨移植、骨搬移术等已成为主要临床技术。随着干细胞生物学、生长因子、新型生物材料和3D生物打印技术的发展,新的治疗手段逐渐增多。In clinical practice,bone defect of long-bone has always been a challenge in orthopedic surgery,which is usually caused by bone defect after open fracture,segment resection of tumor bone,removing necrotic bone in chronic osteomyelitis and other factors.Especially the massive bone defects of long-bone contain not only the massive bone defects,but also poor soft tissue or infection.At present,there are various domestic and overseas treatment methods including main clinical techniques like bone transplantation and bone transport.With the development of stem cell biology,cytokines,new biomaterials and 3D bio-printing technology,new treatments are gradually increasing.

关 键 词：长骨骨缺损 骨缺损 组织工程 细胞因子 富血小板血浆 

分 类 号：R68[医药卫生—骨科学]