移植肾T细胞介导的排斥反应的病理学  

Pathology of T cell-mediated rejection in renal allograft

作　　者：郭晖[1] Guo Hui(Organ Transplantation Institute,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Key Laboratory of Organ Transplantation of Ministry of Education,Key Laboratory of Organ Transplantation of National Health Commission of China,Key Laboratory of Organ Transplantation of Chinese Academy of Medical Sciences,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院器官移植研究所器官移植教育部重点实验室国家卫生健康委员会器官移植重点实验室中国医学科学院器官移植重点实验室,武汉430030

出　　处：《器官移植》2021年第2期134-142,共9页Organ Transplantation

基　　金：中国医学科学院中央级公益性科研院所基本科研业务费专项资金资助(2019PT320014)。

摘　　要：T细胞介导的排斥反应(TCMR)是器官移植排斥反应的主要效应机制之一,也是最常见的急性排斥反应类型。2019年Banff移植病理学诊断标准(Banff标准)根据免疫损伤病变的特征将TCMR分为急性TCMR(aTCMR)和慢性活动性TCMR(caTCMR)。本文对TCMR的基本定义、移植肾Banff标准中TCMR病理学的研究历程和TCMR的基本病变及其诊断分级进行综述,旨在为早期识别、诊断和治疗TCMR提供依据,以预防其进展为caTCMR,进而保障移植肾和受者的长期存活。T cell-mediated rejection(TCMR)is one of the main mechanisms of rejection in organ transplantation,which is also the most common type of acute rejection.Based on Banff classification on allograft pathology(Banff classification)in 2019,TCMR can be divided into acute TCMR(aTCMR)and chronic active TCMR(caTCMR)according to the characteristics of immune lesions.In this article,the basic definition of TCMR,the research progress on TCMR pathology according to Banff classification for renal allograft,and the basic pathological changes and diagnostic grading of TCMR were reviewed,aiming to provide evidence for early identification,diagnosis and treatment of TCMR and prevent the progression of TCMR into caTCMR,thereby guarantying the long-term survival of both the renal allograft and recipient.

关 键 词：Banff移植病理学诊断标准(Banff标准) T细胞介导的排斥反应(TCMR) 抗体介导的排斥反应(AMR) 慢性移植物血管病(CAV) 慢性移植物损伤指数(CADI) 肾小管萎缩 间质纤维化 动脉内膜炎 

分 类 号：R617[医药卫生—外科学] R36[医药卫生—临床医学]