2020年肾移植研究大盘点——来自中国的声音  

Research highlights of renal transplantation in 2020:voice from China

作　　者：罗子寰[1] 孙启全[1] Luo Zihuan;Sun Qiquan(Department of Renal Transplantation,the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China)

机构地区：[1]中山大学附属第三医院肾移植科,广州510630

出　　处：《器官移植》2021年第2期169-176,共8页Organ Transplantation

基　　金：国家自然基金面上项目(81970650、81770753、81800663、81800661、81800662);国家重点研发计划项目(2018YFA0108804)。

摘　　要：肾移植是终末期肾病患者改善生存质量、回归正常生活的首选途径。随着医疗技术与免疫抑制剂的不断更新发展,移植肾的短期存活时间显著延长,但其长期存活问题仍亟待解决。肾缺血-再灌注损伤(IRI)、急性排斥反应、慢性移植肾失功、肾脏纤维化等因素仍是影响移植肾存活的几大难题,相关研究一直是肾移植领域的热点。同时,2020年是不平凡的一年,新型冠状病毒肺炎(新冠肺炎)疫情对各行各业发展的影响巨大,与肾移植相关的研究报道亦呈百家争鸣之态。本文就我国2020年肾移植相关的临床与基础研究的前沿热点以及肾移植领域新冠肺炎相关的研究做一综述,以期提供新的治疗思路和策略。Renal transplantation is the optimal approach to improve the quality of life and restore normal life for patients with end-stage renal diseases.With the development of medical techniques and immunosuppressants,the shortterm survival of renal graft has been significantly prolonged,whereas the long-term survival remains to be urgently solved.Renal ischemia-reperfusion injury(IRI),acute rejection,chronic renal allograft dysfunction,renal fibrosis and other factors are still the major problems affecting the survival of renal graft.Relevant researches have always been hot spots in the field of renal transplantation.Meantime,2020 is an extraordinary year.The novel coronavirus pneumonia(COVID-19)pandemic severely affects the development of all walks of life.Researches related to renal transplantation have also sprung up.In this article,the frontier hotspots of clinical and basic studies related to renal transplantation and the COVID-19 related researches in the field of renal transplantation in China were reviewed,aiming to provide novel therapeutic ideas and strategies.

关 键 词：肾移植 排斥反应 缺血-再灌注损伤(IRI) 新型冠状病毒肺炎 单细胞测序技术 程序性细胞死亡蛋白配体1 氨甲酰化促红细胞生成素 细胞游离DNA BK病毒相关性肾病 

分 类 号：R617[医药卫生—外科学]