线粒体动力学调控对肾缺血-再灌注损伤的影响  

Effect of the regulation of mitochondrial dynamics on renal ischemia-reperfusion injury

作　　者：闫晓冬 王强[2] Yan Xiaodong;Wang Qiang(Hebei North University,Zhangjiakou 075000,China;不详)

机构地区：[1]河北北方学院,河北张家口075000 [2]首都医科大学附属北京友谊医院

出　　处：《器官移植》2021年第2期226-231,共6页Organ Transplantation

基　　金：国家自然科学基金(82070765);医学免疫学国家重点实验室开放课题(NKMI2020K05)。

摘　　要：缺血-再灌注损伤(IRI)是肾移植术后早期移植肾功能障碍的主要原因之一。我国器官移植已经进入公民逝世后器官捐献时代,供者心肺复苏风险增加、低灌注时间和热缺血时间延长等可导致移植肾IRI,影响受者和移植肾的近期及远期临床结局。在IRI等应激状态下,以线粒体分裂和融合的动态调控为主要表现的线粒体动力学机制对线粒体的生物学功能具有重要影响,其损伤引发的细胞凋亡是导致急性肾损伤的关键环节,主要表现为线粒体动力学调控机制失调。本文综述了线粒体动力学调控对肾IRI影响机制的研究进展,以期为改善肾移植临床结局提供参考。Ischemia-reperfusion injury(IRI)is one of the main causes of early graft dysfunction after renal transplantation.In China,organ transplantation has entered into the era of organ donation after citizen’s death.The increased risk of cardiopulmonary resuscitation,prolonged hypoperfusion time and warm ischemia time of donors may lead to IRI of the graft,and affect the short-and long-term clinical prognosis of the recipient and graft.Under IRI and other stress conditions,the mechanism of mitochondrial dynamics,mainly manifested by dynamic regulation of mitochondrial division and fusion,exert critical effect upon the biological function of mitochondria.Cell apoptosis caused by mitochondrial injury is the key event leading to acute kidney injury,which is mainly manifested by the imbalance of the regulatory mechanism of mitochondrial dynamics.In this article,the research progress on the regulatory mechanism of mitochondrial dynamics on renal IRI was reviewed,aiming to provide reference for improving the clinical outcomes of renal transplantation.

关 键 词：缺血-再灌注损伤(IRI) 肾移植 线粒体分裂 线粒体融合 分裂蛋白(Fis)1 融合蛋白(Mfn) 动力相关蛋白(Drp)1 视神经萎缩症蛋白(OPA)1 

分 类 号：R617[医药卫生—外科学] R692[医药卫生—临床医学]