铜掺杂生物活性玻璃的生物医学应用  

Biomedical applications of copper-impregnated bioactive glass

作　　者：韩雅卉 刘晨光 王士斌[1,2] 陈爱政 Yahui Han;Chenguang Liu;Shibin Wang;Aizheng Chen(Institute of Biomaterials and Tissue Engineering,Huaqiao University,Xiamen 361021,China;Fujian Provincial Key Laboratory of Biochemical Technology,College of Chemical Engineering,Huaqiao University,Xiamen 361021,China)

机构地区：[1]华侨大学生物材料与组织工程研究所,厦门361021 [2]华侨大学化工学院,福建省生物化工技术重点实验室,厦门361021

出　　处：《科学通报》2020年第36期4262-4271,共10页Chinese Science Bulletin

基　　金：国家自然科学基金(81971734,U1605225,31800794);福建省科技创新团队发展计划资助。

摘　　要：生物活性玻璃作为一种既能与骨组织键合又能与软组织连接的活性材料,可通过降解过程实现对活性离子的控制释放,在临床生物医学方面得到长足发展.本文综述了近年来合成的铜掺杂生物活性玻璃的基本特征,并对相关生物医学应用研究进展进行介绍,对研究中存在的问题和面临的挑战进行深入剖析.其中,基本特征内容包括结构及分类,具体细分为45S5型、1393型、70S型和1393 B3型等;生物医学应用进展内容涵盖抗菌、抗癌、骨/软骨修复再生及血管生成.Bioactive glass(BG)is generally reckoned as an active constituent that both bonds with skeleton and connects with cartilage.This active material often releases the active ions in a controlled fashion via degradation,which is of particular interest in clinical medicine.However,monodispersed bioactive glass without modification still exists limitations,e.g.,aggregation or lower activities both in vitro and in vivo.Owing to its unique morphology,distinctive cell uptake process,excellent degradation and biomineralization ability,as well as certain high biosafety,functionalized bioactive glass plays a key role in diverse biomedical applications such as bioimaging,gene/drug delivery and wound healing,facilitating the selfrepair and regeneration of tissues.The interesting physicochemical properties of bioactive glass can be adjusted by appropriately selecting active ions,especially metal ions,as impregnated components to alter original bridging oxygen(BO)network to non-bridging oxygen(NBO)structure.In terms of the difference in matrix,bioactive glass is generally devided into three types,i.e.,silicate,borate,and phosphate-based architectures.As a universal element in human physiological fluids,copper ions can also be impregnated in the structure of bioactive glass,in which these species not only affect the signal pathway and metabolic activity,but also serve as essential cofactors for many enzymes.After the ion exchange with the surrounding fluidic environment,copper ions can be precisely released at the desired site,minimizing the adverse effects.On the one hand,the impregnated copper ions inhibit the activity of osteoclast and stimulate the generation and aggregation of collagens,which significantly impact on the formation and healing of skeleton and cartilage.On the other hand,these copper species not only upregulate the expresssion of fibroblast growth factor(FGF)-2 and hypoxia inducible factor(HIF)-1α,but also enhance the production of endothelial nitric oxide synthase,subsequently promoting the proliferation and

关 键 词：铜掺杂生物活性玻璃 抗菌 癌症治疗 成骨 成血管 

分 类 号：R318.08[医药卫生—生物医学工程]