lncRNA与自身免疫性疾病CD4^(+)T淋巴细胞亚群分化的关系研究进展  

Relationship between lncRNA and the differentiation of CD4^(+)T lymphocyte subsets in autoimmune diseases

作　　者：刘楠[1] 李纳[1] 马晓华[1] 朱琳[1] 时程程 LIU Nan;LI Na;MA Xiao-hua;ZHU Lin;SHI Cheng-cheng(Department of Pharmacy,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院药学部,河南郑州450000

出　　处：《药学学报》2020年第12期2793-2799,共7页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金面上项目(31570357);河南省高等学校重点科研项目计划(17A310011).

摘　　要：长链非编码RNA(lncRNA)具有广泛的生物学功能,在表观遗传、细胞周期和细胞分化等生命活动中均有调控作用,且能影响免疫细胞的发育分化与免疫系统稳态的维持。CD4^(+)T细胞亚群是具有不同功能的异质性细胞,能促进T细胞和B细胞等免疫细胞的增殖与分化,协调免疫细胞之间的相关作用。自身免疫性疾病(AID)是一种自身抗原免疫反应引起的慢性炎症性疾病,在疾病的发生及活动期均有lncRNA与CD4^(+)T细胞亚群的参与。本文将针对lncRNA与AID CD4^(+)T细胞亚群分化的关系进行综述。Long non-coding RNA(lncRNA)has a wide range of biological functions in epigenetic,cell cycle,cell differentiation and other life activities,and that affect the development and differentiation of immune cells and the maintenance of homeostasis in the immune system.CD4^(+)T cell subsets are heterogeneous cells with different functions,including promoting the proliferation and differentiation of T cells,B cells and other immune cells,and coordinating related functions between immune cells.Autoimmune disease(AID)is a chronic inflammatory disease caused by an autoantigen immune reaction.lncRNA and CD4^(+)T cell subsets are involved in the occurrence and progression of the disease.This article reviews the relationship between lncRNA and the differentiation of AID CD4^(+)T cell subsets.

关 键 词：长链非编码RNA CD4^(+)T细胞亚群 自身免疫性疾病 系统性红斑狼疮 类风湿性关节炎 银屑病 

分 类 号：R967[医药卫生—药理学]