生物钟系统调控机体代谢的分子机制及中药干预研究进展  

The molecular mechanism by which the circadian rhythm regulates body metabolism and research progress on intervention in the circadian rhythm by traditional Chinese medicine

作　　者：陈振山 张耀文 王小明[2,3,4] 田振华 蒋海强 齐冬梅[2,3,4] CHEN Zhen-shan;ZHANG Yao-wen;WANG Xiao-ming;TIAN Zhen-hua;JIANG Hai-qiang;QI Dong-mei(School of Pharmaceutical Sciences,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Experimental Center,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Shandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic Research,Jinan 250355,China;Key Laboratory of Traditional Chinese Medicine Classical Theory,Ministry of Education,Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东中医药大学药学院,山东济南250355 [2]山东中医药大学实验中心,山东济南250355 [3]山东省中医药基础研究重点实验室,山东济南250355 [4]山东中医药大学,教育部中医药经典理论重点实验室,山东济南250355

出　　处：《药学学报》2020年第12期2818-2826,共9页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81774173);2019年山东省高等学校“青创科技计划”立项(2019KJM005);2018年山东省自然科学基金重大基础研究项目(ZR2018ZC1157).

摘　　要：昼夜节律是生物体适应外界环境的昼夜周期性变化的一种内在调控机制,在机体的代谢过程中具有重要的作用,通过参与机体内多个器官的代谢途径来达到调控机体稳态的作用。当饮食时间、作息颠倒、睡眠障碍等外源性因素引起机体的昼夜节律发生紊乱时,机体发生代谢综合征的风险明显提高。本文旨在阐述昼夜节律与机体代谢之间的关系,并总结消化系统、肝脏系统、肾脏系统和胆汁酸的昼夜节律调节分子机制,综述中药干预昼夜节律的研究进展,为后续昼夜节律的中药研究和分子机制研究提供合理的、有价值的参考依据。Circadian rhythm is an internal regulatory mechanism that allows organisms to adapt to circadian changes in the external environment,and can regulate the body's steady state by affecting the metabolic pathways of multiple organs.When exogenous factors such as eating time,worktime changes,and sleep disturbances cause the body's circadian rhythm to be disrupted,the risk of developing metabolic syndrome is significantly increased.This article explores the relationship between circadian rhythm and body metabolism and summarizes the molecular mechanisms by which circadian rhythm regulates the digestive system,liver and bile acid production,and kidney function.We review research progress on intervention in the circadian rhythm by traditional Chinese medicine and provide a reasonable and valuable basis for follow-up studies on the role of traditional Chinese medicine in research on the molecular mechanisms of regulation of circadian rhythm.

关 键 词：生物钟 代谢 分子机制 中药 

分 类 号：R917[医药卫生—药物分析学]