近红外发光的稀土分子探针在生物成像中的设计及应用  

Design and applications of NIR lanthanide molecular probes for bioimaging and biosensing

作　　者：朱晓飞 金国庆[1] 张俊龙 Xiao-Fei Zhu;Guo-Qing Jin;Jun-Long Zhang(Beijing National Laboratory for Molecular Sciences,State Key Laboratory of Rare Earth Materials Chemistry and Applications,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China;School of Chemistry and Life Science,Changchun University of Technology,Changchun 130012,China)

机构地区：[1]北京大学化学与分子工程学院,北京100871 [2]长春工业大学化学与生命科学学院,长春130012

出　　处：《中国科学：化学》2020年第11期1575-1584,共10页SCIENTIA SINICA Chimica

基　　金：国家重点基础研究发展计划(编号:2015CB856301);国家自然科学基金(编号:21571007,21621061,21778002,21861162008);吉林省教育厅项目(JJKH20200647KJ);吉林省科技厅项目(20200403154SF)资助。

摘　　要：近红外生物成像是一种实时监测各种生理和病理过程、实现生物实体可视化的前沿技术,具有背景干扰少、时空分辨率高、组织穿透能力强等优点,在临床成像研究和应用方面具有巨大潜力,受到日益广泛的关注.其中,近红外发光分子探针的设计、性质及应用至关重要,已经成为决定近红外生物成像领域发展的关键因素.稀土配合物具有小尺寸、低毒性、长寿命、大Stokes位移、抗光漂白、独特的线状发射光谱(元素特征的f-f跃迁)等优点,成为新兴的近红外发光探针,展现出极好的生物医学应用前景.本文综述了近红外稀土分子探针的设计原理和研究进展,结合近年来其在生物医学方面的应用,展望了其发展的方向和趋势以及对稀土化学生物学发展的推动作用.Near-infrared(NIR,700–1700 nm)imaging has emerged as an advanced technology for real-time monitoring of various physiological and pathological procedures and visualization of biological entities.NIR imaging recently gains increasing attention owing to the less background interference,deeper tissue penetration,higher signal-to-noise ratio and temporal/spatial resolution.Furthermore,how to design NIR luminescent molecular probes becomes critical in biological NIR imaging.Lanthanide molecular probes have a promising prospective for the merits such as small size,low toxicity,long decay lifetime,low photobleaching and f-f transition of characteristic element emission.In this minireview,we summarized the sensitization principle and design strategy of NIR Ln molecular probes and the relevant biomedical applications.

关 键 词：近红外稀土配合物 荧光探针 生物成像 生物传感 稀土化学生物学 

分 类 号：O657.3[理学—分析化学] R318[理学—化学]