Larvicidal Evaluation of Aedes aegypti and Antioxidant,Cytotoxic and Antimicrobial Potential of the Aqueous Acid Extract of Pseudoxandra cuspidata(ANNOACEAE).  

作　　者：Ranggel Carvalho Simões Rosany Lopes Martins Erica de Menezes Rabelo Alex Bruno Lobato Rodrigues Ana Luzia Ferreira Farias Patrick de Castro Cantuária Marlon de Oliveira do Nascimento Sheylla Susan Moreira da Silva de Almeida 

机构地区：[1]Laboratory of Pharmacognosy and Phytochemistry of the Federal University of Amapá.Rodovia Juscelino Kubistchek,KM-02.Jardim Marco Zero-Macapá-AP,Brazil [2]Plant Taxonomy Laboratory,Institute of Scientific and Technological Research of the State of Amapá,Highway Jucelino Kubistichek,Km 10,68903419,Macapá,Brazil

出　　处：《Journal of Pharmacy and Pharmacology》2021年第2期53-61,共9页药剂与药理学（英文版）

摘　　要：The Anonnaceae family has 2,500 species and 135 genera, which has about 14 representatives of species in Brazil,including Pseudoxandra cuspidata. The objective of this research was to study the aqueous-acid extract of P. cuspidata, evaluatingits antioxidant, larvicidal, antimicrobial and cytotoxic potential. In the preliminary phytochemical analysis, there were positivity toorganicacids and alkaloids. Inhibitory Activity of EAA was 65% against DPPH. The AAE presented to A. Salina nauplii at LC50%of 600.79 μg/mL for a periodof 24 hours. In relation to larvicidal activity to Aedes aegypti intermediates, AAE presented the LC50%in 24 Hours of 475.91 ppm and 290.73 ppm in 48 Hours. Regarding the antimicrobial action, the EAA presented 50 mg/mL MIC forP. Aeruginosa and MBC at 100 mg/mL, and for S. aureus it presented MIC of 50 mg/mL and did not present MBC. This researchcharacterized the presence of alkaloids and organicacids present in the aqueousacid extract of P. cuspidata. The extract presentedlowtoxicity in relation to the microcrustacean A. salina. It also had a relevant antioxidant potential (65% of Inhibition),larvicidalaction considered effective, antimicrobialaction for both P. Aeruginosa and S. Aureus even did not present bactericidalaction.

关 键 词：Pseudoxandra DPPH Artemia salina Aedes aegypti. 

分 类 号：R28[医药卫生—中药学]